Anti -Ciap2 Rabbit Primary Polyclonal Antibody
China Anti -Ciap2 Rabbit Primary Polyclonal Antibody, Find details about China Primary Antibody, Antibodies from Anti -Ciap2 Rabbit Primary Polyclonal Antibody
Product Information
| Description | cIAP2 rabbit polyclonal |
| Protein full name | Baculoviral IAP repeat-containing protein 3 |
Synonyms | Cellular inhibitor of apoptosis 2, C-IAP2, Birc3, Inhibitor of apoptosis protein 1, mIAP1, RING-type E3 ubiquitin transferase BIRC3 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse cIAP2 |
Isotype | IgG |
Purity | Affinity purification |
| Subcellular location | Nucleus, Cytoplasm |
Predicted MW. | 67 kDa |
Observed MW. | 67 kDa |
| Uniprot ID | O08863, Q5XIW4 |
Applications
| Applications | WB | IHC | IF |
| Species | Mouse, Rat | Mouse | Mouse |
| Dilution | 1: 500-1: 1000 | 1: 1500-1: 3000 | 1: 750-1: 1500 |
| Positive tissue | thymus, testes,lymph nodes | lung, testis, spleen | lung, testis, spleen |
Background
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner.
Images
| Western blot analysis of cIAP2 (GB111051) at dilution of 1: 750 Lane 1: Mouse thymus tissue lysate Lane 2: Mouse lymph nodes tissue lysate Lane 3: Mouse testes tissue lysate Lane 4: Rat thymus tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using cIAP2 (GB111051) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse testis using cIAP2 (GB111051) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using cIAP2 (GB111051) at dilution of 1: 3000 |
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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