Anti -Foxo4/Afx Rabbit Polyclonal Primary Antibodies
China Anti -Foxo4/Afx Rabbit Polyclonal Primary Antibodies, Find details about China Primary Antibody, Primary Antibodies from Anti -Foxo4/Afx Rabbit Polyclonal Primary Antibodies
Anti -FOXO4/AFX Rabbit Polyclonal Primary Antibodies
Product Information| Description | FOXO4 rabbit polyclonal |
Protein full name | Forkhead box protein O4 |
Synonyms | Fork head domain transcription factor AFX1, FOXO4, AFX, AFX1, MLLT7 |
| Immunogen | Recombinant protein corresponding to Human FOXO4 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 54 kDa |
Observed MW. | 54 kDa |
| Uniprot ID | P98177, D4A433 |
Applications
| Applications | WB |
| Species | Human, Rat |
| Dilution | 1: 500-1: 1000 |
| Positive tissue | 293T, MDA-MB-231, Jurkat |
Background
FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias.
Images
| Western blot analysis of FOXO4 (GB111173) at dilution of 1: 1000 |
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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