Erythromycin Estolate Tablets in The Treatment of The Following Infections

China Erythromycin Estolate Tablets in The Treatment of The Following Infections, Find details about China Infections, Following Infections from Erythromycin Estolate Tablets in The Treatment of The Following Infections

Model NO.
CF013
Model NO.
CF013
[Drug name]



General name: Erythromycin granule



Product name: Relying on erythromycin granules



Erythromycin Estolate Granules



Pinyin full code: Yituohongmeisukeli



Main ingredients The main ingredients of this product are: relying on erythromycin.



[Characteristics] This product is a granule with flavoring agent; Fragrant; Sweet taste.



[Indications/Functions] 1. Erythromycin granules can be used as an alternative drug for penicillin allergic patients in the treatment of the following infections: acute tonsillitis, acute pharyngitis and sinusitis caused by hemolytic streptococcus and streptococcus pneumoniae; Scarlet fever and cellulitis caused by hemolytic streptococcus; Diphtheria and diphtheria carriers; Gas gangrene, anthrax, tetanus; Actinomycosis; Syphilis; Listeriosis, etc. 2. Legionella disease. 3. Mycoplasma pneumoniae pneumonia. 4. Chlamydia pneumonia. 5. Other genitourinary infections caused by chlamydia and mycoplasma. 6. Chlamydia trachomatis conjunctivitis. 7. Oral infection caused by anaerobe. 8. Campylobacter jejuni enteritis. 9. Whooping cough. 10. Rheumatic fever recurrence, infective endocarditis (rheumatic heart disease, congenital heart disease, heart valve replacement surgery), oral, upper respiratory tract medical operations of prophylactic drugs (alternative to penicillin).




[Specifications and models] 75mg*10 bags



[Usage and Dosage] Oral administration, 1 ~ 2g per day for adults, divided into 3 ~ 4 times, and 20 ~ 30mg/kg per day for children, divided into 3 ~ 4 times. The treatment of Legionellosis is 0.5 ~ 1.0g once for adults, 4 times a day. When used for prevention of recurrence of rheumatic fever, 0.25g once, twice a day. When used as prophylactic agent for infective endocarditis, 1g orally 1 hour before surgery and 0.5g again 6 hours after surgery.



1. Compared with other erythromycin preparations, hepatotoxic reactions occur more frequently after taking this product. Patients may develop fatigue, nausea, vomiting, abdominal pain, rash and fever after taking this product for several days or 1 to 2 weeks. Can appear jaundice sometimes, liver function test shows silt gallbladder, after stopping medicine often can restore. 2. Gastrointestinal reactions include diarrhea, nausea, vomiting, middle and upper abdominal pain, mouth and tongue pain, gastric hypopnea, etc. The incidence is related to the dose size. 3. Large dose (≥4g/ day) application, especially in patients with liver and kidney diseases or elderly patients, may cause hearing loss, mainly related to high blood concentration (12mg/L), which can be recovered after drug withdrawal. 4. Allergic reactions include drug fever, rash, and eosinophilia, with an incidence of about 0.5% ~ 1%. 5. Others: Occasional arrhythmia, oral or vaginal candida infection.



[Forbidden] It is contraband for those allergic to erythromycin.



[Precautions] 1. Cross allergy: allergy to one erythromycin preparation may also be allergic to other erythromycin preparations. 2. ALT, AST, AKP and bilirubin were more common in patients taking etoerythromycin granules than those taking other erythromycin preparations. 3. Hemolytic streptococcal infection should be treated with etoerythromycin granules for at least 10 days to prevent the occurrence of acute rheumatic fever. 4. Use with caution in patients with chronic liver disease or liver function impairment. 5. Patients with reduced renal function generally do not need to reduce dosage. 6. Because the sensitivity of different bacteria to erythromycin has certain difference, it should be done drug sensitivity test. 7. Diagnostic interference: erythromycin can interfere with the fluorescence determination of the Higerty method, resulting in a dramatic increase in the measured value of urinary catecholamines. Serum alkaline phosphatase, bilirubin, alanine aminotransferase and aspartate aminotransferase may be increased. Please read the instructions carefully and follow the doctor's advice.



[Children's medication] is not clear.



[Drug use in elderly patients] is not clear.



[Medication for pregnant and lactating women] Etonoerythromycin granules can pass through the placenta and enter the fetal circulation, and the possibility of hepatotoxic reaction is increased after taking Etonoerythromycin granules, so it is not suitable for pregnant women to use it. 2. Erythromycin has a considerable amount into breast milk, lactating women should stop breastfeeding.



[Drug Interaction] 1. Etythromycin granules can inhibit the metabolism of antiepileptic drugs such as carbamazepine and valproic acid, leading to toxic reactions caused by the increase of the blood concentration of the latter drugs. Erythromycin granules combined with alfentanil can inhibit the metabolism of the latter and prolong its action time. The combination of etoerythromycin granules with asmizole or terfinadine and other antihistamines can increase cardiotoxicity, while the combination with cyclosporin can increase the blood concentration of the latter, resulting in nephrotoxicity. 2. It has antagonistic effect with chloramphenicol and lincoamides and is not recommended to be used together. 3. Relying on erythromycin granule as bacteriostatic agent, can interfere with the bactericidal efficacy of penicillin, so when the need for rapid bactericidal action such as treatment of meningitis, the two should not be combined with medication. 4. Erythromycin may lead to prolonged prothrombin time in patients taking warfarin for a long time, increasing the risk of bleeding, especially in elderly patients. When the two must be used together, the warfarin dose should be adjusted appropriately, and the prothrombin time should be closely observed. 5. In addition to dihydroxypropionophylline, the combination of erythromycin granules and xanthine can reduce the liver clearance of aminophylline, leading to an increase in serum aminophylline concentration and/or an increase in toxic reactions. The decrease of aminophylline clearance was directly proportional to the serum peak value of etoerythromycin granules. Therefore, the dosage of xanthine should be adjusted during and after the combination of the two. 6. Combined with other hepatotoxic agents may enhance hepatotoxicity. 7. Large doses of etoerythromycin granules in combination with ototoxic agents may increase ototoxicity, especially in patients with reduced renal function. 8. When combined with lovastatin, it can inhibit its metabolism and increase blood concentration, which may cause rhabdomyolysis. When combined with midazolam or triazolam, it can reduce their clearance and enhance their action.



[Drug overdose] should be stopped in time to give symptomatic and supportive treatment. It is rarely eliminated after hemodialysis or peritoneal dialysis.



[Pharmacological Toxicology] This product belongs to macrolide antibiotics, is the dodecyl sulfate of erythromycin propionate, and has antibacterial activity against Staphylococcus, Streptococcus and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Borutella pertussis can also be sensitive to this product. It also has antimicrobial activity against all kinds of anaerobic bacteria except Bacteroidetes fragilis and Fusobacteria. It also has an inhibitory effect on Legionella, Campylobacter foetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. It is a bacteriostatic, but also bactericidal against certain bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (the "P" site), blocking the binding of transfer ribonucleic acid (T-RNA) to the "P" site, and also blocking the shift of the polypeptide chain from the host site (the "A" site) to the "P" site, thus inhibiting the bacterial protein synthesis. This product is only effective on active dividing bacteria.



[Pharmacokinetics] It is absorbed quickly on an empty stomach or after meals and is relatively stable in gastric acid. The protein binding rate was 90% ~ 99%. After being taken orally, it decomposes into erythromycin propionate ester in the stomach and intestines, and partially hydrolyze into free erythromycin in the blood, which has antibacterial effect. The peak plasma concentrations (Cmax) of 0.25g and 0.5g were reached at 1.4mg/L and 4.2mg/L, respectively, 2 hours after oral administration. After absorption, except for cerebrospinal fluid and brain tissue, it is widely distributed in all tissues and body fluids, especially in liver, bile and spleen. The concentration in kidney, lung and other tissues can be several times higher than that in blood, and the concentration in bile can be 10 ~ 40 times more than that in blood. In the subcutaneous tissue, the concentration of sputum and bronchial secretion was also high, and the concentration of sputum was similar to the concentration of drug in blood. The concentration in the chest, ascites, pus, etc. can reach effective levels. A certain amount of this product (about 33% of the blood drug concentration) can enter the prostate and seminal vesicle, but it is not easy to penetrate the blood-cerebrospinal fluid barrier, and the concentration of cerebrospinal fluid is only about 10% of the blood drug concentration when meningeal inflammation occurs. It can enter fetal blood and be discharged into breast milk. The concentration of fetal blood drug is 5% ~ 20% of that of maternal blood drug, and the concentration of drugs in breast milk can reach more than 50% of that of blood drug. Apparent volume of distribution (VD) was 0.9L/kg. Free erythromycin is metabolized in the liver, with a blood elimination half-life (t1/2?). Is 1.4 ~ 2 hours, and the blood half-life of patients without urine can be extended to 4.8 ~ 6 hours. Erythromycin is mainly concentrated in the liver and excreted from the bile, and is circulated through enterohepatic circulation. About 2% ~ 5% of the oral amount and 10% ~ 15% of the injected amount are filtered out from the glomerulus, and the concentration in urine can reach 10 ~ 100mg/L. There is also a certain amount in feces. Blood or peritoneal dialysis is rarely removed, so it is unnecessary to use it after dialysis.



To hide from light, to store in sealed storage.



[Effective period] 24 months



[Approval Number] National medicine approval H44022180




FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese


Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.


Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.



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