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Cefixime Used to Treat Infections Caused by Sensitive Bacteria

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Model NO.
Cefixime
Pharmaceutical Technology
Chemical Synthesis
Drug Reg./Approval No.
Cefixime
Drug Ad Approval No.
Cefixime
Trademark
TP
Transport Package
Cefixime
Specification
Cefixime
Origin
China
Model NO.
Cefixime
Pharmaceutical Technology
Chemical Synthesis
Drug Reg./Approval No.
Cefixime
Drug Ad Approval No.
Cefixime
Trademark
TP
Transport Package
Cefixime
Specification
Cefixime
Origin
China
Cefixime Used to treat infections caused by sensitive bacteria
Cefixime Used to Treat Infections Caused by Sensitive Bacteria

Cefixime (Cefixime) is a third-generation oral cephalosporin antibiotic, suitable for the treatment of respiratory, urinary and biliary tract infections caused by sensitive bacteria.

Cefixime is highly stable against the β-lactamase produced by Gram-negative bacilli, and its antibacterial effect against Gram-negative bacilli is stronger than that of the first and second generation cephalosporins.

The second generation cephalosporin.

At present, cefixime drugs approved by the State Food and Drug Administration are available in various dosage forms such as tablets, capsules, dispersible tablets, dry suspensions and granules, all of which are prescription drugs.

Cefixime is used to treat the following infections caused by sensitive bacteria:

1. Respiratory system infections, such as bronchitis, pneumonia, etc.;

2. Urinary system infections, such as pyelonephritis, cystitis, urethritis, etc.;

3. Biliary tract infections, such as cholecystitis and cholangitis;

4. Others, such as otitis media, sinusitis, scarlet fever, etc.

Clinical applicationCefixime is administered orally.

Patients with renal insufficiency need to adjust the dose.

When the creatinine clearance rate is ≥60ml/min, it should be used according to the common dosage and administration interval;
the creatinine clearance rate is between 21~60ml/min, and the normal dose should be given 75% according to the normal administration interval;

The rate is less than 20ml/min, and 50% of the normal dose is given according to the normal dosing interval.

Adverse reactionsMost of the adverse reactions of cefixime are brief and mild.

1. Allergic reactions: common rash, urticaria, erythema, itching, fever, edema, dyspnea, general flushing, angioedema, and anaphylactic shock are rare.

2. Gastrointestinal reactions: common diarrhea, upset stomach, rare chest burning sensation, lack of appetite, nausea, vomiting, abdominal pain, abdominal distension, constipation and stomatitis caused by dysbacteriosis, oral candidiasis, pseudomembranous enteritis, etc. .

3. Respiratory system: Rarely accompanied by fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, interstitial pneumonia and pulmonary eosinophil infiltration (PIE syndrome).

4. Blood system: common eosinophilia, rare neutropenia, hemolytic anemia, and thrombocytopenia.

5. Liver: Alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase are common and jaundice is rare.

6. Kidney: Urea nitrogen and acute renal insufficiency are rare.

7. Others: rare headache, dizziness, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) and vitamin K and B deficiency.

Precautions

1. The safety and effectiveness of cefixime in pregnant women and lactating women and children under 6 months of age have not been established. Pregnant women need to weigh the pros and cons before use. The US Food and Drug Administration (FDA) classifies cefixime's pregnancy safety as B. Lactating women should stop breastfeeding when using cefixime.

2. The following patients should be used with caution:

patients with a history of penicillin allergy;

those who have allergies and their immediate family members;

patients with renal insufficiency;

patients with oral administration difficulties or non-oral nutrition intake, systemic cachexia State patients (due to possible vitamin K);

patients with pseudomembranous enteritis.

3. The course of treatment for Streptococcus pyogenes infection requires at least 10 days.

4. When the dosage is the same, the blood concentration of oral suspension is 25% to 50% higher than that of oral tablets.
Patients with otitis media should be treated with suspension.


 

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