Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS 78628-80-5 High Purity Terbinafine Hydrochloride with Low Price
China Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS 78628-80-5 High Purity Terbinafine Hydrochloride with Low Price, Find details about China Terbinafine, Terbinafine Hydrochloride from Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS 78628-80-5 High Purity Terbinafine Hydrochloride with Low Price
Basic Info.
Mf
C21h26cln
Appearance
White Powder
MOQ
1kg
Grade
Pharmaceutical Grade
Test Method
HPLC
Mesh
100% Pass 80 Mesh
OEM Service
Accept
MSDS
Available
Shelf Life
2 Years
CAS Number
78628-80-5
Einecs
616-640-4
Molecular Weight
327.89
Trademark
Greenway Biotech
Transport Package
Paper Bag or Drum
Specification
1kg/bag; 25kg/drum
Origin
China
HS Code
2942000000
Mf
C21h26cln
Appearance
White Powder
MOQ
1kg
Grade
Pharmaceutical Grade
Test Method
HPLC
Mesh
100% Pass 80 Mesh
OEM Service
Accept
MSDS
Available
Shelf Life
2 Years
CAS Number
78628-80-5
Einecs
616-640-4
Molecular Weight
327.89
Trademark
Greenway Biotech
Transport Package
Paper Bag or Drum
Specification
1kg/bag; 25kg/drum
Origin
China
HS Code
2942000000
Product Desciption
Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS
78628-80-5 High Purity Terbinafine Hydrochloride with Low Price
Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate
in hair, skin, nails, and fatty tissue.
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water.
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase,
an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine
prevents conversion of squalene to lanosterol, ergosterol cannot be synthesize
Function:
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines,
terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is
part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion
of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell
membrane permeability, causing fungal cell lysis.
Application:
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock
itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis).
Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail
infection, typically by a dermatophyte or Candida species. Fungal nail infections are located
deep under the nail in the cuticle to which topically applied treatments are unable to penetrate
in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of
this and may be monitored with liver function tests. Alternatives to oral administration have
been studied.
4. Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Persons
with lupus erythematosus should first discuss possible risks with their doctor before initiation
of therapy.
78628-80-5 High Purity Terbinafine Hydrochloride with Low Price
| Product Name | Terbinafine Hydrochloride |
| Brand Name | Greenway Biotech |
| Purity | 99% |
| MF | C21H26ClN |
| Appearance | White Powder |
| Test Method | HPLC |
Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate
in hair, skin, nails, and fatty tissue.
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water.
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase,
an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine
prevents conversion of squalene to lanosterol, ergosterol cannot be synthesize
Function:
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines,
terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is
part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion
of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell
membrane permeability, causing fungal cell lysis.
Application:
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock
itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis).
Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail
infection, typically by a dermatophyte or Candida species. Fungal nail infections are located
deep under the nail in the cuticle to which topically applied treatments are unable to penetrate
in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of
this and may be monitored with liver function tests. Alternatives to oral administration have
been studied.
4. Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Persons
with lupus erythematosus should first discuss possible risks with their doctor before initiation
of therapy.
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