Hot Salecas 171228-49-2 Posaconazole API for Pharmaceutical Use Powder

China Hot Salecas 171228-49-2 Posaconazole API for Pharmaceutical Use Powder, Find details about China Posaconazole, Posaconazole Price from Hot Salecas 171228-49-2 Posaconazole API for Pharmaceutical Use Powder

Basic Info.

Model NO.

HRK-Posaconazole

Product Name

Posaconazole Powder

Appearance

White Powder

Test

HPLC

C37h42f2n8o4

CAS

171228-49-2

700.78

Active Ingredient

Posaconazole

Sample

Posaconazole Avaliable

Certificate

GMP ISO USP Bp

Assay

90% Min

Grade Standard

Feed Grade, Food Grade, Medicine Grade

Application

Vertinary Raw Materials

Type of Product

Auxiliaries and Other Medicinal Chemicals

Storage

Cool Dry Place

Shelf Life

2 Years Proper Storage

Trademark

Henrikang

Transport Package

1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr

Specification

99% min

Origin

Shaanxi China

Model NO.

HRK-Posaconazole

Product Name

Posaconazole Powder

Appearance

White Powder

Test

HPLC

C37h42f2n8o4

CAS

171228-49-2

700.78

Active Ingredient

Posaconazole

Sample

Posaconazole Avaliable

Certificate

GMP ISO USP Bp

Assay

90% Min

Grade Standard

Feed Grade, Food Grade, Medicine Grade

Application

Vertinary Raw Materials

Type of Product

Auxiliaries and Other Medicinal Chemicals

Storage

Cool Dry Place

Shelf Life

2 Years Proper Storage

Trademark

Henrikang

Transport Package

1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr

Specification

99% min

Origin

Shaanxi China

Product Desciption

Hot saleCAS 171228-49-2 Posaconazole API for Pharmaceutical use powder

Product Name	Hot saleCAS 171228-49-2 Posaconazole API for Pharmaceutical use powder
CAS	171228-49-2
Appearance	White powder
Molecular formula	C37H42F2N8O4
Molecular Weight	700.78
Assay	98%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

What is Posaconazole?

Posaconazole is a triazole antifungal drug. It is used for the prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as HSCT recipients with GVHD or those with hematologic malignancies with prolonged neutropenia from chemotherapy. It is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy. It is also used to treat invasive infections by Candida, Mucor, and Aspergillus species in severely immunocompromised patients.

Function and Application of Posaconazole

Posaconazole is a broadspectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14ademethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membranebound proteins.Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14a demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.

Hot Salecas 171228-49-2 Posaconazole API for Pharmaceutical Use Powder