API Terbinafine HCl 98% CAS 78628-80-5 Terbinafine HCl Terbinafine Powder
China API Terbinafine HCl 98% CAS 78628-80-5 Terbinafine HCl Terbinafine Powder, Find details about China Terbinafine HCl, Terbinafine from API Terbinafine HCl 98% CAS 78628-80-5 Terbinafine HCl Terbinafine Powder
Basic Info.
Product Name
Terbinafine HCl
CAS No.
78628-80-5
Mf
C21h25n
Appearance
White Crystalline Powder
Application
Pharmaceutical Intermediates
Grade Standard
Medicine Grade
Sample
Avaliable
Certificate
GMP Coa ISO9001
Shelf Life
2 Years
Storage
Cool and Dry Place
Form
Powder
Trademark
JULONG
Transport Package
Foil Bag & Drum
Specification
98%
Origin
China
Product Name
Terbinafine HCl
CAS No.
78628-80-5
Mf
C21h25n
Appearance
White Crystalline Powder
Application
Pharmaceutical Intermediates
Grade Standard
Medicine Grade
Sample
Avaliable
Certificate
GMP Coa ISO9001
Shelf Life
2 Years
Storage
Cool and Dry Place
Form
Powder
Trademark
JULONG
Transport Package
Foil Bag & Drum
Specification
98%
Origin
China
Product Desciption
Product Description
| API Terbinafine Hcl 98% CAS 78628-80-5 Terbinafine Hcl Terbinafine Powder | |
| Product Name: | Terbinafine HCL |
| Purity: | 98%min |
| Appearance: | White Crystalline Powder |
| CAS No.: | 78628-80-5 |
| EINECS: | 245-385-8 |
| Molecular Formula: | C21H25N·HCl |
| Molecular Weight: | 327.9 |
What is Terbinafine Hcl ?
Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate in hair, skin, nails, and fatty tissue.
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water.
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesize.
Real Shot
Function & Application
Terbinafine is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.
4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.
4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.
Test Report
Items | Specifications | Results |
Appearence | White or almost white powder | Conforms |
Solubility | Very slightly or slightly soluble in water , freely soluble in anhydrous ethanol and in methanol, slightly soluble in acetone | Conforms |
| Identification | ||
1)IR spectrum 2)UV spectrum | 1)correspond to standard IR 2)Correspond to standard UV | Conforms |
Loss on drying | No more than 0.5% | 0.10% |
Sulphated ash | No more than 0.1% | 0.04% |
Related substance | Impurity B is not more than 0.15% | 0.006% |
Impurity E is not more than 0.05% | Negative | |
Single unspecified impurity is not more than 0.01% | 0.018% | |
Total impurity is not more than 0.3% | 0.066% | |
Microbiology limit | Aerobic bacteria not more than 1000/g Total amount of fungi not more than 100/g Escherichia coli: none | Comply |
Assay | >99.0% | 99.8% |
FAQ
1. Who are we?
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us?
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates
4. Why should you buy from us not from other suppliers?
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries
5. What services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,Western Union,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
Company Profile
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development
Package & Delivery & Payment Terms
Why Choose Us?
1. All inquiries will be replied within 12 hours.
Package & Delivery & Payment Terms
Why Choose Us?
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
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