Itraconazol is an artificially synthetic clotrimazol, being a broad-spectrum synthetic antifungal agent. Its antimicrobial spectrum and antimicrobial mechanism is similar to clotrimazol, but has strong antibacterial activity against Aspergillus.

_{It exerts its anti-fungal effect through changing the fungal cell membrane permeability with antibacterial activity against superficial and deep fungal pathogens. Its antibacterial spectrum is broader and stronger than ketoconazol, being able to inhibit the ergosterol synthesis of fungal cell membrane, thus playing the antifungal effect.}

_{This product is suitable for the treatment of Dermatophytes (Trichophyton, Microsporum, Flocculent Epidermophyton), Yeast [Cryptococcus neoformans, Pityrosporum, Candida (including Candida albicans, Candida glabrata and candida krusei)], Aspergillus, Histoplasma, Paracoccidioides brasiliensis, Sporothrix schenckii, Hormodendrum, Cladosporium, Blastomyces dermatitidis and various kinds of other types of yeasts and fungi. Itraconazol is not able to inhibit the growth of Rhizopus and Mucor.}

 

Function & Application 

_{1) Itraconazol has a broader spectrum of activity than fluconazol (but not as broad as voriconazol or posaconazol). In particular, it is active against Aspergillus which fluconazol is not.}

_{2) It is also prescribed for systemic infections, such as aspergillosis, candidiasis, and cryptococcosis}

_{3) Itraconazol has also recently been explored as an anticancer agent for patients with basal cell carcinoma.}

_{The imidazol antifungal agents for the triazol ring, through inhibiting the activation of cytochrome P-450, including oxidase and peroxidase, disable the 14, alpha-methyl sterols to be dehydrogenated and be converted to ergosterol, so that the growth and proliferation of fungi are inhibited. They have strong lipophilicity and penetrate through the biofilm to inhibit the binding of the membrane to the fungus.}

_{The antibacterial spectrum is similar to ketoconazol. It is effective in the treatment of superficial fungal diseases such as vaginal and oral candidiasis as well as skin mycosis. Furthermore, it is expected to become the highly-efficient and safe drugs for the treatment of deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for the treatment of vulvovaginal candidiasis, pityriasis and skin fungal disease pityriasis caused by sensitive fungi.}

_{It can be used for the synthesis of broad-spectrum azol antifungal agents for the treatment of systemic infection caused by deep fungus. It can also be used for the treatment of candidiasis and aspergillosis.}

_{It is used for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.}

_{It is anti Fungal and used in the treatment of stomach upset/ indigestion and other gastrointestinal conditions.}

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development

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