China Chromium Picolinate 14639-25-9/Lactoferrin 112163-33-4/146897-68-9/Pyrithione Zinc 13463-41-7 Zinc Pyrithione/Hydroxyapatite 1306-06-5/84625-61-6 Itraconazole, Find details about China Itraconazole, 84625-61-6 from Chromium Picolinate 14639-25-9/Lactoferrin 112163-33-4/146897-68-9/Pyrithione Zinc 13463-41-7 Zinc Pyrithione/Hydroxyapatite 1306-06-5/84625-61-6 Itraconazole
Introduction
Product Name | Itraconazole | ||
Cas No. | 84625-61-6 | Delivery time | 7-10 days |
EINECS No. | 617-596-9 | Storage | 2-8 degrees Celsius |
Appearance | white powder | MW | 705.63 |
Shelf life | 2 years | MF | C35H38Cl2N8O4 |
Itraconazole is a synthetic triazole derivative. It is a synthetic broad-spectrum antifungal drug. Its antibacterial spectrum and antibacterial mechanism are similar to clotrimazole, but it has strong antibacterial activity against Aspergillus. The permeability of fungal cell membrane exerts antibacterial activity, and it has antibacterial activity against pathogens of superficial and deep fungal infections. Its antibacterial spectrum is broader and stronger than ketoconazole. It can inhibit the synthesis of fungal cell membrane ergosterol, thereby exerting antifungal effect. This product is effective against dermatophytes (Trichophyton, Microsporum, Epidermophyton flocculus), yeasts (Cryptococcus neoformans, Saccharomyces sp., Candida (including Candida albicans, Candida glabrata and Candida krusei)], Aspergillus, Histoplasma, Paracoccosis Brazil, Sporothrix schenckii, Color fungi, Cladosporium, Blastomyces dermatitis, and various other yeasts and fungi Has an inhibitory effect. But itraconazole cannot inhibit the growth of Rhizopus and Mucor.
Application
Itraconazole is indicated for the treatment of the following diseases:
1. For systemic fungal infections, such as aspergillosis, candidiasis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, Brazilian paracoccosis, blastomycosis And many other rare systemic or tropical fungal diseases.
2. Used for oral cavity, pharynx (foreign data), esophagus (foreign data), vulvovaginal Candida infection, fungal conjunctivitis, fungal keratitis.
3. Used for superficial fungal infections, such as tinea hands, tinea corporis, tinea cruris, tinea versicolor, etc.
4. For onychomycosis caused by dermatophytes and (or) yeasts.
Specification
Inspection characteristic | Specification | Test result | ||
Appearance | White to almost white power | Conform | ||
Identification | IR | Conform | ||
Optical Rotation (20°) | -0.10° to +0.10° | Conform | ||
Melting range | 166ºC-170ºC | 166ºC-169ºC | ||
Related substances | Impurity 1 | 0.50%max | Conform | |
Impurity 2 | 0.50%max | Conform | ||
Impurity 3 | 0.50% max | Conform | ||
Impurity 4 | 0.50%max | Conform | ||
Impurity 5 | 0.50%max | Conform | ||
Impurity 6 | 0.50%max | Conform | ||
Impurity 7 | 0.50%max | Conform | ||
Unspecified Impurities | 0.10%max | Conform | ||
Total impurities | 1.25%max | 0.81% | ||
Loss on drying | 0.50%max | 0.34% | ||
Residue on ignition | 0.10%max | 0.05% | ||
Assay | 98.5.0%-101.5% | 99.1% |