Density:
1.336 g/cm3
Boiling Point:
438.7 °C at 760 mmHg
Melting Point:
125ºC
Flash Point:
219.1 °C
Storage Temperature:
2-8°C
Refractive index:
1.497
Solubility:
DMSO Solubility : ~44 mg/mL
Biological Activity:
Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Stability:
Stable if stored as directed.
Usage:
Used as an anticonvulsant