Highest Quality 5875 -06-9 Proparacaine Hydrochloride in Stock
China Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock, Find details about China Proparacaine Hydrochloride, Proparacaine HCl from Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock
Basic Info.
Model NO.
proparacaine hydrochloride
Product Name
Proparacaine Hydrochloride
Delivery
Express 5-7 Days Arrive
Other Name
Proparacaine HCl
Key Word
Articaine HCl Powder
Content
Pure Proparacaine Hydrochloride
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
CAS
5875-06-9
Trademark
proparacaine hydrochloride
Transport Package
Express
Specification
25kg/Drum
Origin
China
Model NO.
proparacaine hydrochloride
Product Name
Proparacaine Hydrochloride
Delivery
Express 5-7 Days Arrive
Other Name
Proparacaine HCl
Key Word
Articaine HCl Powder
Content
Pure Proparacaine Hydrochloride
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
CAS
5875-06-9
Trademark
proparacaine hydrochloride
Transport Package
Express
Specification
25kg/Drum
Origin
China
Product Desciption
Non-GMO
Gluten Free
Dairy Free
No artificial colors or flavors
Clean & Pure Powder. No Fillers
Lab Tested for Verification & Guaranteed Purity
From our plant to your door step
| Product name | Proparacaine HCL |
| Other name | Proparacaine hydrochloride |
| CAS register number | 5875-06-9 |
| EINECS | 227-541-7 |
| Molecular formula | C16H27ClN2O3 |
| Molecular weight | 330.85 |
| Assay | 98.5% |
| Appearance | White crystalline powder |
| Package | 1kg/aluminium foil bag or as required |
| Usage | can be used as pharmaceutical material |
Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.
The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.
The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.
| Items | Standards | Results | |
| Appearance | White to light yellow crystalline powder | Complies | |
| Identification | It should be Nitrogen base reaction | Complies | |
| By UV | Complies | ||
| Should display the reaction of chloride differentiated | Complies | ||
| Solubility | Should dissolved in water, warm ethanol and methanol, insoluble in ether and benzene, the solution is neutral to litmus | Complies | |
| Melting Point | 178ºC~185ºC | 180.3~182.1ºC | |
| Loss on Drying | ≤ 0.50% | 0.14% | |
| Residue on Ignition | ≤ 0.15% | 0.03% | |
| Residual Solvents | DMF: ≤880ppm | ND | |
| Ethanol: ≤5000ppm | ND | ||
| Acetone: ≤5000ppm | ND | ||
| Isopropanol: ≤5000ppm | ND | ||
| Toluene: ≤890ppm | ND | ||
| Methanol: ≤3000ppm | ND | ||
| Related Substances | If the impurities are detected, then the total amount of the impurities should be not more than 2.0%. | Complies | |
| Assay (on the anhydrous basis) | 97.0%~103.0% | 99.67% | |
| Reference Standard | USP35 Standard | ||
| Conclusion | The product complied to USP35 standard. | ||
| Storage | Preserve in tight,light-resistant containers in a cool place | ||
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