Plant Extract Liquiritigenin 98% CAS 578-86-9 Antitumor

China Plant Extract Liquiritigenin 98% CAS 578-86-9 Antitumor, Find details about China Liquiritigenin, Liquiritigenin 98% from Plant Extract Liquiritigenin 98% CAS 578-86-9 Antitumor

Basic Info.

Model NO.

liquiritigenin

Shipping Time

3-5 Days

Delivery Time

Usually 7-10 Days

Working Time

7/24

Color

Customized

Types

Herbal Extract

Shipping Method

EMS, DHL, UPS, Usps, Economic Packet, etc

OEM

Available

Origin City

Shenzhen, China

Price

Negotiable

MOQ

100 Grams

Specifications

100 Grams/Foil Bag

Assay

98%

Appearance

White Powder

Packages

100 Grams/Foil Bag, 25kg/Drum

Usage

Cosmetics, Health Products, etc.

Trademark

OEM

Transport Package

Foil Bag

Specification

20*5*30

Origin

China

HS Code

2932999099

Model NO.

liquiritigenin

Shipping Time

3-5 Days

Delivery Time

Usually 7-10 Days

Working Time

7/24

Color

Customized

Types

Herbal Extract

Shipping Method

EMS, DHL, UPS, Usps, Economic Packet, etc

OEM

Available

Origin City

Shenzhen, China

Price

Negotiable

MOQ

100 Grams

Specifications

100 Grams/Foil Bag

Assay

98%

Appearance

White Powder

Packages

100 Grams/Foil Bag, 25kg/Drum

Usage

Cosmetics, Health Products, etc.

Trademark

OEM

Transport Package

Foil Bag

Specification

20*5*30

Origin

China

HS Code

2932999099

Product Desciption

Plant Extract Liquiritigenin 98% CAS 578-86-9 Antitumor

Liquiritigenin is a dihydroflavonoid monomer compound found in licorice, which has physiological effects such as anti-cancer, anti-ulcer, anti-inflammatory and liver protection.

Glycyrrhizin inhibits invasion and metastasis of human melanoma A375 cells by regulating miRNA Studies have shown that flavonoids have antitumor activity. Glycyrrhizin is a dihydroflavonoid monomer compound extracted from natural plant licorice. Previous studies in our laboratory have found that glycyrrhizin can inhibit the growth of human hepatoma SMMC-7721 cells and human cervical cancer Hela cells, and induce apoptosis by regulating apoptosis-related proteins and reactive oxygen species (ROS)-mediated mitochondrial signaling pathways. Inhibition of invasion and metastasis of human lung adenocarcinoma A549 cells by modulating the PI3K/AKT pathway and its downstream matrix metalloproteinase 2 (MMP2) [6]. Glycyrrhizin can down-regulate hsa-miR-4487 expression of hsa-miR-4534, increase the expression of PTEN and TIMP2, and inhibit the expression of p-AKT and MMP2, and finally inhibit the invasion and metastasis of human melanoma A375 cells. Transfection experiments further indicated that the expression of PTEN and TIMP2 was regulated by hsa-miR-4534 and hsamiR-4487, PTEN was a possible target gene of hsa-miR-4534, and TIMP2 was a possible target gene of hsa-miR-4487. The levels of PTEN and TIMP2 caused by glycyrrhizin increased, and the levels of p-AKT and MMP2 decreased due to the down-regulation of hsa-miR-4487 and hsa-miR-4534. Therefore, glycyrrhizin inhibited invasion and metastasis of human melanoma A375 cells. The regulation is inseparable. Effects of glycyrrhizin on proliferation, apoptosis and autophagy of human breast cancer MCF-7 cells Studies have shown that glycyrrhizin can inhibit the proliferation of human cervical cancer HeLa cells and induce apoptosis. Autophagy is a series of biochemical processes in which eukaryotic cells perform "self-digestion" by degrading their own cytoplasm and organelles. It is a physiological mechanism prevalent in normal cells and pathological cells. The low autophagy activity in some tumor cells has a certain relationship with the occurrence of tumors. Anti-tumor drugs can induce autophagy in cells, which have positive and negative effects on tumor cells. The autophagy pathway has a broad prospect as a target for anti-tumor drugs. Moreover, glycyrrhizin can inhibit the growth of human breast cancer MCF-7 cells, and its growth inhibition is associated with apoptosis promotion and autophagy induction.

Appearance	white power
Form	powder
Packing	1kg/bag 25kg/Drum
Shipping	Below 300kg By Air, Above 300kg By Sea
Storage	Placed in a cool and dry place, avoid light and high-temperature
Shelf Life	24months
Shipping time	3-5 days
Leading time	5-7 days after tracking number
Working time	7/24
Payment terms	Western Union, Money Gram, Telegraph Transfer, etc.