China Factory API Provide 99% Nsi-189/Nsi189 Nootropic Powder CAS 1270138-40-3 with Good Price, Find details about China Hot Sale Nsi-189, Good Price Nsi-189 from Factory API Provide 99% Nsi-189/Nsi189 Nootropic Powder CAS 1270138-40-3 with Good Price
Name:Nsi-189,NSI-189 Phosphate
CAS: 1270138-40-3
MF: C19H23N3O3
MW: 341.4
Storage Temp.: 2-8°C
Appearance: white crystals
Usage: Brain health drug;Nootropic
NSI-189 is an experimental, novel potential antidepressant that is under investigation byNeuralstem, Inc. for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration. Research into NSI-189 has been funded by theDefense Advanced Research Projects Agency (DARPA) and the National Institutes of Health(NIH).The mechanism of action of NSI-189 appears to be activation of neurogenesis in thehippocampus and possible enlargement of this structure,[2] but how the drug mediates these effects is unknown and binding studies have so far failed to identify any certain molecular targets for the drug. As stated by Neuralstem, NSI-189 is a "new chemical entity with [a] novel mechanism of action, molecular target yet unknown, but not mediated by SSRI or SNRIor by BDNF release or via any known GPCRs, kinases, or channels." The drug was discovered via high-throughput screening of a library of 10,269 compounds for neurogenic effects in vitro.
1.Nsi-189 can Enhance cognition and memory formation
2.Nsi-189 can Anxiolytic properties
3.Nsi-189 can Anti-depressive effect
4.Nsi-189 can Treatment of Alzheimer's and Parkinson's disease
5.Nsi-189 can Increase coordination
6.Nsi-189 can Improves mood
7.Nsi-189 can Help fight fatigue
8.Nsi-189 can Prevent oxidation within the brain
9.Nsi-189 can Treat alcohol related brain damage
10.Nsi-189 can Prevent caffeine withdrawal symptoms
1. Pterostilbene has lowering blood lipids and cholesterol.
2. Pterostilbene can be used for diabetes.
3. Pterostilbene has anti-inflammatory,antineoplastic,anti-cancer,and antioxidant actions via modulations of gene expression and enzyme activity.
Applications
1) Be useful for treating heart diseases such as high blood pressure and high cholesterol.
2) Can interfere with cancer cell growth and proliferation, as well as induce apoptosis.
3) Be active against HIV by inhibiting virus expression and replication.
4) Accelerating healing of injured skin.
5) Inhibiting oral sugar metabolism and retard growth of certain bacteria.
6) Enhancing bone density and strength.
7) Protecting against carcinogenesis and prove supplementation for sunscreen protection
Product name | NSI-189 | ||
CAS No. | 1270138-40-3 | Packing | 1kg/bag |
Production date | Dec. 15. 2019 | Shelf life | Dec. 14th. 2022 |
Standard adopted | in-house standard | ||
Items of analysis | Specification | Results | |
Appearance | Off-white powder | Confrom | |
Identification | IR and HPLC spectrum shall conform to the standard sample | conform | |
Melting Point | 83ºC~86ºC | 84.3ºC~85.6ºC | |
Loss on Drying | Less than 0.5% | 0.29% | |
Purity(On Dried Base,HPLC) | NLT 99.5 % | 99.62% | |
Total Impurity | Less than 0.5% | 0.33% | |
Residue On Ignition | ≤0.2% | 0.16% | |
Heavy metal | ≤20ppm | conform |
Items | Purity | CAS |
Noopept ♥ Hot sell | 99% | 157115-85-0 |
Sunifiram ♥ Hot sell | 99% | 314728-85-3 |
Unifiram | 99% | 272786-64-8 |
Aniracetam | 99% | 72432-10-1 |
Oxiracetam ♥ Hot sell | 99% | 62613-82-5 |
Pramiracetam | 99% | 68497-62-1 |
Coluracetam ♥ Hot sell | 99% | 135463-81-9 |
Piracetam | 99% | 7491-74-9 |
Fasoracetam | 99% | 110958-19-5 |
PRL-8-53 ♥ Hot sell | 99% | 51352-88-6 |
NSI-189 ♥ Hot sell | 99% | 1270138-40-3 |
NSI-189 phosphate | 99% | 135463-81-9 |
♥ 3% Discount available if you order more than 2 of them. |
What are nootropics?
Nootropics also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, andhormones), by improving the brain's oxygen supply, or by stimulating nerve growth.
Racetams
The racetams are structurally similar compounds, such as pramiracetam, oxiracetam, coluracetam, and aniracetam, which are often marketed as cognitive enhancers and sold over-the-counter. Racetams are often referred to as nootropics, but this property of the drug class is not well established. The racetams have a poorly understoodmechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergicsystems.
Aniracetam
Aniracetam is an ampakine nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer's patients, and temporarily impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in Europe as a prescription drug, but it is not approved by the Food and Drug Administration for use in the United States.
Piracetam
Piracetam is a cognitive enhancer and memory enhancing supplement. Many people across the world use the nootropic, piracetam, to effectively retain knowledge andimprove memory. Piracetam is utilized by both younger and older healthy individuals.
From recent and past clinical studies and research, Piracetam has been determined to support memory and aid individuals experiencing memory loss and difficulties in the ability to retain knowledge. Piracetam may enhance, elevate, and improve cognitive functions and abilities linked and associated to the central nervous system, memory development and memory processes.
Pramiracetam
Pramiracetam is a lipid-soluble nootropic of the Racetam chemical family, and has a relatively similar chemical structure compared to its cousin Aniracetam. However, this nootropic is much stronger than Aniracetam. Pramiracetam has the capabilities of increasing the long term memory of individuals, allowing obtained information and knowledge to be recalled more easily. Considering that the high-affinity choline uptake (HACU) is increased implies an increase in the synthesis and release of Acetylcholine. The information shows how this smart drug increases both the Hippocampal Acetylcholine activity and the learning and memory encoding process.
Sunifiram
Sunifiram is a research ampakine that is becoming very popular amongst researchers. As an ampakine, it works to improve the ability of the AMPA glutamate receptors. Sunifiram works by stimulating the AMPA receptor currents therefore improving the glutamate signal. This is believed to be the main method of action however there are several other applications of this compound.
Unifiram
Unifiram is the cousin of sunifiram. It is very similar in structure and the effects are supposedly similar. Unifiram is thought to be a slightly more potent compound than sunifiram. It is becoming very popular amongst nootropics researchers worldwide.
Coluracetam
Coluracetam is another nootropic in racetam chemical class. The effects of coluracetam are supposedly similar to the cousin racetam, pramiracetam. Its' main function is to improve High Affinity Choline Uptake (HACU). HACU has some great effects on the cholinergic applications on cognitive function. This is another exciting compound indeed.
IDRA-21
This is another ampakine nootropic and it belongs to the benzothiadiazine family. IDRA-21 is less researched than sunifiram and unifiram. Preliminary animal studies have shown positive results on reducing drug induced defects. The compound does not appear to show neurotoxicity when administered alone. IDRA-21 is a highly sought after compound for avid nootropic researchers.
PRL-8-53
PRL-8-53 is of great interest to nootropic researchers. It has had some human studies which showed positive responses in cognitive function. One study showed that the compound could help retrieve lost memories (hypermnesia). Research on PRL-8-53 in medical applications has come to a standstill however many independent nootropic researchers have got it on their crosshairs.
The method of action of PRL-8-53 is not fully understood. It does possess cholinergic properties. It is also thought that PRL-8-53 may potentiate dopamine functions while inhibiting serotonin. Many aspect of this compound are still a mystery.
Product Name | CAS No. |
Smart Drugs | |
alpha-GPC | CAS 28319-77-9 |
Aniracetam | CAS 72432-10-1 |
CDP-Choline | CAS 987-78-0 |
Centrophenoxine | CAS 3685-84-5 |
Choline | CAS 123-41-1 |
Choline Bitartrate | CAS 87-67-2 |
Choline Chloride | CAS 67-48-1 |
Citicoline Sodium | CAS 33818-15-4 |
Coluracetam(MKC 231) | CAS 135463-81-9 |
DMAE | CAS 5988-51-2 |
Donepezil | CAS 120014-06-4 |
Fasoracetam | CAS 110958-19-5 |
Fladrafinil | CAS 90212-80-9 |
GABA | CAS 56-12-2 |
Galantamine | CAS 357-70-0 |
Hordenine HCl | CAS 6027-23-2 |
Huperzine A | CAS 120786-18-7 |
Hydrafinil | CAS 1689-64-1 |
Idebenone | CAS 58186-27-9 |
IDRA 21 | CAS 22503-72-6 |
Magnesium L-Threonate | CAS 778571-57-6 |
Memantine HCL | CAS 41100-52-1 |
Mexidol | CAS 127464-43-1 |
Noopept | CAS 157115-85-0 |
Oxiracetam | CAS 62613-82-5 |
Phosphatidylserine | CAS 51446-62-9 |
Picamilon | CAS 34562-97-5 |
Picamilon Sodium | CAS 62936-56-5 |
Piracetam | CAS 7491-74-9 |
Pramiracetam | CAS 68497-62-1 |
PRL-8-53 | CAS 51352-87-5 |
Rivastigmine Tartrate | CAS 129101-54-8 |
Semax | CAS 80714-61-0 |
Spongouridine | CAS 3083-77-0 |
Sulbutiamine | CAS 3286-46-2 |
Sunifiram | CAS 314728-85-3 |
Uridine | CAS 58-96-8 |
Vincamine | CAS 1617-90-9 |
Vinpocetine | CAS 42971-09-5 |
Sleep Aid | |
Melatonine | CAS 73-31-4 |
Phenibut | CAS 1078-21-3 |
Suvorexant(MK-4305) | CAS 1030377-33-3 |
Tasimelteon | CAS 609799-22-6 |
Antidepressant | |
5-HTP | CAS 56-69-9 |
Agomelatine | CAS 138112-76-2 |
Escitalopram Oxalate | CAS 219861-08-2 |
NSI-189 | CAS 1270138-40-3 |
NSI-189 Phosphate | CAS 1270138-41-4 |
Sertraline HCL | CAS 79559-97-0 |
Tianeptine | CAS 66981-73-5 |
Tianeptine Sodium | CAS 30123-17-2 |
Tianeptine Sulfate | CAS 1224690-84-9 |
Trazodone HCL | CAS 25332-39-2 |
Longevity | |
Agmatine Sulfate | CAS 2482-00-0 |
Artemisinin | CAS 63968-64-9 |
Beta-NMN | CAS 1094-61-7 |
Chondroitin Sulfate | CAS 9007-28-7 |
CLA | CAS 121250-47-3 |
Coenzyme Q10 | CAS 303-98-0 |
Curcumin | CAS 458-37-7 |
Glucosamine | CAS 3416-24-8 |
Glutathione | CAS 70-18-8 |
L-DOPA | CAS 59-92-7 |
Piperine | CAS 94-62-2 |
PQQ | CAS 72909-34-3 |
Quercetin | CAS 117-39-5 |
How to place an order
1.Send the specification, quantity and address to us , we will offer you a good Door to Door price for you.
2.Send the invoice and payment information to you.
3.Sent the goods to you by Fedex, DHL, EMS.. as soon as get your payment.
4.Send the tracking no. to you.
5. Get the goods.
Delivery
Delivery time: 3 days after get the payment.
Payment Terms : T/T,West Union,Paypal
Packing
1. 25kg/drum : 25kg net weight,28kg gross weight; Packed in a cardboard-drum with two plasticbags insideSize: 510mm high, 350mm diameter
2. 1kg/bag (1kg net weight, 1.2kg gross weight, packed in an aluminum foil bag) OR as per your request.
Name | CAS NO. | Usage |
AICAR | 2627-69-2 | acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown |
MK2866 | 841205-47-8 | medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy. |
MK-677 | 15972-10-0 | for the treatment of frailty in the elderly |
LGD-4033 | 1165910-22-4 | pharmacological profile similar to that of enobosarm, Ostarine,MK-2866 |
GW1516 | 317318-70-0 | For obesity, diabetes, dyslipidemia and cardiovascular disease |
Andarine(S4) | 401900-40-0 | partial agonist, intended mainly for treatment of benign prostatic hypertrophy |
SR9009 | 1379686-30-2 | under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice |
RAD140 | 1182367-47-0 | New generation for gaining mass and cutting edges |
YK11 | 431579-34-9 | YK11: a SARM and myostatin inhibitor in one |
AC262356 | 870888-46-3 | New SARMS |
SR9011 | 1379686-29-9 | New SARMS |
S23 | 1010396-29-8 | New SARMS |
GW0724 | 317318-84-6 | New SARMS |
Product name | CAS No. | Specification |
LGD-4033 | 1165910-22-4 | 98%min |
SR-9009 | 1379686-30-2 | 98%min |
YK-11 | 1370003-76-1 | 98%min |
MK-2866 (ostarine) | 841205-47-8 | 99%min |
GW-501516 | 317318-70-0 | 98%min |
S4 | 401900-40-1 | 98%min |
SR9009 | 1379686-30-2 | 98%min |
Company Advantage
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1,High quality and competetive price. we can offer COA Certificate and official Invoice;
2,We are manufacturer, products plenty in stock and orders can be delivered in the first time;
Products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.
3,Rich experienced packing and delivery department,packages well disguised,fast and safe delivery, pass rate above 99%;
4,Express company:EMS,HKEMS,Fedex,TNT,UPS,DHL etc;
5,We have reship policy if parcel can't reach your hands due to custom;
6,24/7 online after-sales service