99% High Purity Pharmaceutical Intermediate Memantine CAS 19982 -08-2 with Safe Delivery
China 99% High Purity Pharmaceutical Intermediate Memantine CAS 19982-08-2 with Safe Delivery, Find details about China Memantine, CAS 19982-08-2 from 99% High Purity Pharmaceutical Intermediate Memantine CAS 19982-08-2 with Safe Delivery
99% High Purity Pharmaceutical Intermediate Memantine CAS 19982-08-2 with Safe Delivery
Basic Information
| Product name | Memantine |
| Cas number | 19982-08-2 |
| Molecular formula | C12H22ClN |
| Molecular weight | 215.76 |
| Appearance | white powde |
| Melting point | 153 |
| Boiling point | 239.8 at 760 mmHg |
| Relative density | 1.046 |
What is Memantine?Memantine hydrochloride is a raw material. It should be prescribed by experienced doctors in the diagnosis and treatment of Alzheimer's dementia and guided by patients. Treatment can only begin when there are caregivers around the patient who regularly supervise the patient's medication. Dementia should be diagnosed in accordance with current diagnostic criteria and guidelines.
Description
Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Treatment should only be continued if beneficial effects are seen. It is taken by mouth.
Memantine was approved for medical use in the United States in 2003. It is available as a generic medication. In 2017, it was the 149th most commonly prescribed medication in the United States, with more than four million prescriptions
Memantine Benefits
Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European.
The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity.
Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs).
Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.
Medical Use
Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors.One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia.
Memantine has been associated with a modest improvement; with small positive effects on cognition, mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimer's disease. There does not appear to be any benefit in mild disease.
Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. The UK National Institute of Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia. Effects in autism are unclear. Recent scientific journal reports are showing guarded promise with severe obsessive compulsive disorder.
COA
Item | Requirements | Test Results |
appearance | White or almost white crystalline powder | White crystalline powder |
Identification | IR | Comply |
Related substance | 1-methyladamantane ≤0.3% 1,3,5 -trimethyladamantane ≤0.3% Unknow impuritiy ≤0.1% Total impurity ≤0.5% | 0.13% 0.14% <0.1% <0.4% |
Residue on ignition | ≤0.1% | 0.06% |
Heavy matal | ≤10ppm | <10ppm |
Loss on drying | ≤0.5% | 0.29% |
Assay | 98.5-101.0% | 99.13% |
Residual Solvents | Ethyl Acetat: ≤0.5% Ethanol: ≤0.5% | 0.08% 0.12% |
PH | 4.5-5.5 | 5.3 |
Microbial Limits | Max 5*102 aerobes and fungl per 1g E. Coli: Negative Salmonella: Negative
| Pass |
Size of distributed particles | Pass 100μ m | Conforms |
Conclusion | Meet the requirements | |
Memantine HPLC & NMR Test Report-Yinherb Lab
Our Company
Wuhan Biocar Pharmaceutical Co., Ltd. is a high-tech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.
FAQ
You can send your Purchase order, or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma
Invoice with our bank details for your confirmation, then you can make payment accordingly.
2: How to make the payment?
We can accept L/C, T/T, West Union, Money Gram etc.
3: What's your MOQ?
For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts
from 100g and 1kg.
4: When will you deliver the goods?
If we have inventory, generally we can arrange shipment after receipt of payment 2 to 3 days. If not, it will be decided by the
time of the factory production.
Our advantages
1.High quality with competitive price.
2. All purity>99%.
3. We are manufacturer and can provide high quality products with factory price.
Fast and safe delivery.
1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
We have clients throughout the world.
1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2. Market feedback and goods feedback will be appreciated , meeting customers' requirement is our responsibility.
3. High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
5.Sample order are welcome.
6.NMR,HPLC and COA can be supplied
7.We can supply sample for testing
8.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!
You Might Also Like
Triac 0-10V Dali Dimmable Recessed LED Downlight/ COB LED Ce......
GMP Factory Supply Food Grade Phycocyanin Spirulina Extract
Table Tennis Racket with Rubber + Bag Ping Pong Bat
3mh Cool Giant Fat Inflatable Cat Cartoon for Advertising
Mslfp14 17*17 Wired Box Size X-ray Digital Flat Panel Detect......
Portable Glass Shape Edge Polishing Machine
A4 A3 Paper Wrapping Machine
Stainless Steel Angle Tube Strainer
Sinchold 9220/20/45 Forged Steel Welded Crane Rail Clips
Warehouse Tent Made by Superb Tent
Thyristor Rectified CO2 MIG Mag Arc Welding Machine