CAS 314728-85-3 Nootropic Supplements Sunifiram / DM 235 CAS 314728-85-3 for Memory Enhancement
CAS 314728-85-3 Nootropic Supplements Sunifiram / DM 235 CAS 314728-85-3 for Memory Enhancement
CAS 314728-85-3 Nootropic Supplements Sunifiram / DM 235 CAS 314728-85-3 for Memory Enhancement

Sunifiram
systematic (iupac) name: 1-benzoyl-4-propanoylpiperzine
cas no: 314728-85-3
mf: c14h18n2o2
appearance: white crystal

Name	Sunifiram
Systematic (IUPAC) name	1-benzoyl-4-propanoylpiperzine
CAS number	314728-85-3
Formula	C14H18N2O2
Appearance	white powder
Application	a piperazie derived research chemical which has nootropic effects
Stock	bulk in stock
Assay	99%

sunifiram is a research ampakine that is becoming very popular amongst researchers. sunifiram (dm-235) is a piprazine derived ampakine drug which acts as a positive allosteric

modulator of ampa receptors, and has nootropic effects in animal studies with significantlyhigher potency thanpiracetam. a number of related compounds are known, the best known

this enhancement by sunifiram is associated with an increase inphosphorylation of ampar through activation of protein kinase ii(camkii) and an increase in phosphorylation of nmdar through activation of protein kinase c α (pkcα). more specifically, sunifiram stimulates the glycinebinding site of nmdar with concomitant pkcαactivation through src kinase. enhancement of pkcα activity triggers to potentiate hippocampal ltp through camkii activation. sunifiram improves cognitive deficits via cam kinase ii andprotein kinase c activation.
 

Sunifiram (DM-235) is a piperzine derived ampakine drug which acts as a positive allosteric
modulator of AMPA receptors, and has nootropic effects in animal studies with significantly
higher potency than piracetam. A number of related compounds are known, the best known
being unifiram (DM-232)
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.

 

Function
1.Sunifiram activates AMPA-mediated neurotransmission.
2.Enhancing LTP in a bell-shaped dose-response relationship.
3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.
4. Packing &Storage

Application:

The exact mechanism to explain how Sunifiram is able to have such a strong cognitive benefit is yet to be found, but scientist have identified some interesting models to show how some of these attributes may be better understood. One such mechanism is that of NMDA signaling which was confirmed after Sunifiram dosages were maintained for over 7 days.

This can explain some of the NMDA-dependent Long Term Potentiation seen with Sunifiram use.Further studies have shown rodents with memory impairment (centered around the hippocampus) benefitted from Sunifiram administration, when their ability to complete training sessions was measured. Finally, Sunifiram injections were able to cause the release of acetylcholine, which was detected in the prefrontal cortex of laboratory mice.

 

For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs, Senile Dementia, Acetylcholine Release Enhancers.

Sunifiram (DM-235) is a synthetic derivative of Piracetam, although due to breaking the pyrrolidone backbone it is no longer in the Racetam class of drugs (yet by being derived from them, it is still commonly associated with this class). Sunifiram has mechanisms similar to Nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Its anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile.

 

 

 

 

I 'm Ben
 

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