China Pharmaceutical Raw Materials Albuterol Sulfate CAS 51022-70-9 for Weight Loss Albuterol Sulphate, Find details about China Albuterol Sulfate, 51022-70-9 from Pharmaceutical Raw Materials Albuterol Sulfate CAS 51022-70-9 for Weight Loss Albuterol Sulphate
Pharmaceutical Raw Materials Albuterol Sulfate CAS 51022-70-9 For Weight Loss Albuterol Sulphate
Pharmaceutical Raw Materials Albuterol Sulfate CAS 51022-70-9 For Weight Loss Albuterol Sulphate
Pharmaceutical Raw Materials Albuterol Sulfate CAS 51022-70-9 For Weight Loss Albuterol Sulphate
CAS: 51022-70-9
MF: C13H23NO7S
MW: 337.39
EINECS: 242-424-0
Synonyms: 1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanolsulfate ;ASMAVEN SULFATE;COBUTOLIN;2-(TERT-BUTYLAMINO)-1-(4-HYDROXY-3-HYDROXYMETHYLPHENYL)ETHANOL HEMISULFATE;5-[2-(TERT-BUTYLAMINO)-1-HYDROXYETHYL]-2-HYDROXYBENZYL ALCOHOL HEMISULFATE;ALPHA1-[(TERT-BUTYLAMINO)METHYL]-4-HYDROXY-1,3-BENZENEDIMETHANOL HEMISULFATE SALT;ALPHA-1-[[(1,1-DIMETHYLETHYL)AMINO]METHYL]-4-HYDROXY-1,3-BENZENEDIMETHANOL HEMISULFATE;ALPHA1-[[(1,1-DIMETHYLETHYL)AMINO]METHYL]-4-HYDROXY-1,3-BENZENEDIMETHANOL SULPHATE
Melting point: 180 °C
Flash point:250 °C
storage temp. Store at RT
solubility 1 M NaOH: soluble50 mg/ml, clear to slightly hazy, yellow-green
Water Solubility Soluble in water and 1M sodium hyroxide (50 mg/ml).
Merck 216
Description
Albuterol Sulfate or Albuterol is also known as Salbutmol. It is a drug that relaxes and dilates the bronchial passageway and improves the passages of air into the lungs. It is also used in treating hypertension or arrhythmia and decreases force and rate of heart contractions by blocking beta-adrenergic receptors of the automatic nervous system. Albuterol sulfate inhalers are particularly prescribed to those people with asthma and with utmost physical allergies. Albuterol may be ordained as a syrup (orally taken) or a tablet. This medication does not cure asthma or any diseases that cause breathing problems, but will only help prevent or calms any attacks.
Specification
Test Items | Specification | Test Results | |
Appearance | white oralmost white,crystalline powder | Conform | |
Solubility | Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylen chloride. | Conform | |
Identification | A | The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. | Conform |
B | Infraed absorption spectrophotometry. | Conform | |
C | Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. | Conform | |
D | An orange-red color develop in methylee chloride layer. | Conform | |
E | It geves reaction (a) of sulphates. | Conform | |
Appearance of solution | Solution S is clear and not more intensely coloured than reference solution in BY6. | Conform | |
Optical rotation | negative 0.10° to +0.10°determined on solution S. | +0.01° | |
Acidity or alkalinity | NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. | Conform | |
Related substances | Impurity J ≤0.20% | Conform | |
Any other impurity ≤0.30% | Conform | ||
Total impurity ≤1.0% | Conform | ||
Boron | ≤50ppm | Conform | |
Sulphated ash | ≤0.10% | 0.06% | |
Loss on drying | ≤0.5% | 0.30% | |
Assay(on dried basis) | 98.0~101.0% | 99.5% | |
Conclusion | The test results above BP2009 |
Application
Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.
It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbuamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.
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