Purchase High Purity Minocycline Hydrochloride CAS 13614-98-7from China
Purchase High Purity Minocycline Hydrochloride CAS 13614-98-7from China, Find details about China Klinomycin Minocycline, Minomycin Nsc 141993 from Purchase High Purity Minocycline Hydrochloride CAS 13614-98-7from China
Basic Info.
Model NO.
Minocycline hydrochloride
Product Name
Minocycline Hydrochloride
CAS
13614-98-7
Mf
C23h28cln3o7
MW
493.94
Einecs
237-099-7
Mol File
13614-98-7.Mol
Melting Point
205-210° (DEC)
Trademark
BIOCAR
Transport Package
Aluminum Foil Bag or as Required
Specification
1kg/bag-25kg/drum
Origin
China
HS Code
29413020
Model NO.
Minocycline hydrochloride
Product Name
Minocycline Hydrochloride
CAS
13614-98-7
Mf
C23h28cln3o7
MW
493.94
Einecs
237-099-7
Mol File
13614-98-7.Mol
Melting Point
205-210° (DEC)
Trademark
BIOCAR
Transport Package
Aluminum Foil Bag or as Required
Specification
1kg/bag-25kg/drum
Origin
China
HS Code
29413020
Product Desciption
Purchase high purity Minocycline hydrochloride CAS 13614-98-7from China
Basic Information
Manufacturing Process
Preparation of 7-(N,N'-Dicarbobenzyloxyhydrazino)-6-Demethyltetracycline: A1.0 g portion of 6-demethyltetracycline was dissolved in a mixture of 9.6 ml and 10.4 ml of at -10°C. The mixturewas allowed to warm to 0°C. A solution of 0.86 g of dibenzyl azodicarboxylatein 0.5 ml of was added dropwise and the mixture was stirredfor 2 hours while the temperature was maintained at 0°C. The reactionmixture was added to ether. The product was filtered off, washed with etherand then dried. The 7-(N,N'-dicarbobenzyloxyhydrazino)-6-demethyltetracycline was identified by paper chromatography.
Reductive Methylation of 7-(N,N'-Dicarbobenzyloxyhydrazino)-6-Demethyl-6-Deoxytetracycline to 7-Dimethylamino-6-Demethyl-6-Deoxytetracycline: Asolution of 100 mg of 7(N,N'-dicarbobenzyloxyhydrazino)-6-demethyl-6-deoxytetracycline in 2.6 ml of 0.4 ml of 40% aqueous ormaldehyde solution and 50 mg of 5% palladium on carbon catalyst washydrogenated at room temperature and two atmospheres pressure. Uptake ofthe hydrogen was complete in 3 hours. The catalyst was filtered off and thesolution was taken to dryness under reduced pressure. The residue wastriturated with ether and then identified as 7-dimethylamino-6-demethyl-6-deoxytetracycline by comparison with an authentic sample, according to USPatent 3,483,251.
Uses
Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
General Description
Minocycline, 7-dimethylamino-6-demethyl-6-deoxytetracycline(Minocin, Vectrin), the most potent tetracycline currentlyused in therapy, is obtained by reductive methylationof 7-nitro-6-demethyl-6-deoxytetracycline. It was releasedfor use in the United States in 1971. Because minocycline,like doxycycline, lacks the 6-hydroxyl group, it is stablein acids and does not dehydrate or rearrange to anhydroor lactone forms. Minocycline is well absorbed orally togive high plasma and tissue levels. It has a very long serumhalf-life, resulting from slow urinary excretion and moderateprotein binding. Doxycycline and minocycline, alongwith oxytetracycline, show the least in vitro calcium bindingof the clinically available tetracyclines. The improved distributionproperties of the 6-deoxytetracyclines have been attributedto greater lipid solubility.
Perhaps the most outstanding property of minocyclineis its activity toward Gram-positive bacteria, especiallystaphylococci and streptococci. In fact, minocycline hasbeen effective against staphylococcal strains that are resistantto methicillin and all other tetracyclines, includingdoxycycline. Although it is doubtful that minocyclinewill replace bactericidal agents for the treatment of lifethreateningstaphylococcal infections, it may become auseful alternative for the treatment of less serious tissueinfections. Minocycline has been recommended for thetreatment of chronic bronchitis and other upper respiratorytract infections. Despite its relatively low renal clearance,partially compensated for by high serum and tissuelevels, it has been recommended for the treatment of urinary tract infections. It has been effective in the eradicationof N. meningitidis in asymptomatic carriers.
Our Advantages
1.For products exported we can offer COA Certificate and official PI.
2.We are manufacturer with own lab and factory, can provide high quality products with factory price.
3.Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7x24h for you to contact.
4.Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
5.Customs pass and satisfied rate ≥99%.
6.For hot sale products we have stock in there for transferring.
7.We have different couriers to different countries.
8.We have clients throughout the world.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
Q&A:
1.Will you supply samples for test the quality?
We'd like to offer the samples for the quality evaluation,the shipping cost is borne by customers.
2.What is the payment term?
T/T, Western Union or L/C and Money Gram and BTC .
3.What is your package?
Powder: PE bag, glass bottle or PTFE bottle for inner packing
Liquid: glass bottle or PTFE bottle for inner packing
Bulk order: Fiber drum or steel drum.
4.What is your delivery term and delivery period?
FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you.The sample within 5 days, and bulk order within 7 days.
5.How to delivery by express?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
8.How to make orders?
A: Send inquiry to us,we do the offer. Payment via Western Union, Moneygram, Bank Account ect.. Then we will arrange shipping. After delivery we will offer tracking No..
Basic Information| Product Name: | Minocycline hydrochloride |
| Synonyms: | KlinoMycin, Minocycline chloride, MinoMycin, NSC 141993;(4S,4aS,5aR,12aS)-4,7-Bis(diMethylaMino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide hydrochloride;2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aR,12aS)-;Minocycline hydrochloride Solution, 100ppm;Minocycline hydrochloride, >=98%;[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-te;10,12,12a-tetrahydroxy-1,11-dioxo--monohydrochloride;2-(Amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione hydrochloride |
| CAS: | 13614-98-7 |
| MF: | C23H28ClN3O7 |
| MW: | 493.94 |
| EINECS: | 237-099-7 |
| Product Categories: | DAYPRO;antibiotic;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;API;Antibacterial;Peptide Synthesis/Antibiotics |
| Mol File: | 13614-98-7.mol |
Manufacturing ProcessPreparation of 7-(N,N'-Dicarbobenzyloxyhydrazino)-6-Demethyltetracycline: A1.0 g portion of 6-demethyltetracycline was dissolved in a mixture of 9.6 ml and 10.4 ml of at -10°C. The mixturewas allowed to warm to 0°C. A solution of 0.86 g of dibenzyl azodicarboxylatein 0.5 ml of was added dropwise and the mixture was stirredfor 2 hours while the temperature was maintained at 0°C. The reactionmixture was added to ether. The product was filtered off, washed with etherand then dried. The 7-(N,N'-dicarbobenzyloxyhydrazino)-6-demethyltetracycline was identified by paper chromatography.
Reductive Methylation of 7-(N,N'-Dicarbobenzyloxyhydrazino)-6-Demethyl-6-Deoxytetracycline to 7-Dimethylamino-6-Demethyl-6-Deoxytetracycline: Asolution of 100 mg of 7(N,N'-dicarbobenzyloxyhydrazino)-6-demethyl-6-deoxytetracycline in 2.6 ml of 0.4 ml of 40% aqueous ormaldehyde solution and 50 mg of 5% palladium on carbon catalyst washydrogenated at room temperature and two atmospheres pressure. Uptake ofthe hydrogen was complete in 3 hours. The catalyst was filtered off and thesolution was taken to dryness under reduced pressure. The residue wastriturated with ether and then identified as 7-dimethylamino-6-demethyl-6-deoxytetracycline by comparison with an authentic sample, according to USPatent 3,483,251.
Uses
Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
General Description
Minocycline, 7-dimethylamino-6-demethyl-6-deoxytetracycline(Minocin, Vectrin), the most potent tetracycline currentlyused in therapy, is obtained by reductive methylationof 7-nitro-6-demethyl-6-deoxytetracycline. It was releasedfor use in the United States in 1971. Because minocycline,like doxycycline, lacks the 6-hydroxyl group, it is stablein acids and does not dehydrate or rearrange to anhydroor lactone forms. Minocycline is well absorbed orally togive high plasma and tissue levels. It has a very long serumhalf-life, resulting from slow urinary excretion and moderateprotein binding. Doxycycline and minocycline, alongwith oxytetracycline, show the least in vitro calcium bindingof the clinically available tetracyclines. The improved distributionproperties of the 6-deoxytetracyclines have been attributedto greater lipid solubility.
Perhaps the most outstanding property of minocyclineis its activity toward Gram-positive bacteria, especiallystaphylococci and streptococci. In fact, minocycline hasbeen effective against staphylococcal strains that are resistantto methicillin and all other tetracyclines, includingdoxycycline. Although it is doubtful that minocyclinewill replace bactericidal agents for the treatment of lifethreateningstaphylococcal infections, it may become auseful alternative for the treatment of less serious tissueinfections. Minocycline has been recommended for thetreatment of chronic bronchitis and other upper respiratorytract infections. Despite its relatively low renal clearance,partially compensated for by high serum and tissuelevels, it has been recommended for the treatment of urinary tract infections. It has been effective in the eradicationof N. meningitidis in asymptomatic carriers.
Our Advantages
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast. We have ready goods in stock.
4.Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
5.We could make our price discount if you place a substantial order with us.
FAQ
1. Can i get some samples?
Yes, we can supply free sample, but the shipping cost be paid by our customers.
2. How to start orders or make payments?
Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union, L/C, Moneygram, BTC ,Escrow.
3. How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
4. How long is lead time?
We deliver goods within 3 days for small order, 7-10 days for bulk order.
5. How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1.For products exported we can offer COA Certificate and official PI.2.We are manufacturer with own lab and factory, can provide high quality products with factory price.
3.Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7x24h for you to contact.
4.Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
5.Customs pass and satisfied rate ≥99%.
6.For hot sale products we have stock in there for transferring.
7.We have different couriers to different countries.
8.We have clients throughout the world.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
Q&A:1.Will you supply samples for test the quality?
We'd like to offer the samples for the quality evaluation,the shipping cost is borne by customers.
2.What is the payment term?
T/T, Western Union or L/C and Money Gram and BTC .
3.What is your package?
Powder: PE bag, glass bottle or PTFE bottle for inner packing
Liquid: glass bottle or PTFE bottle for inner packing
Bulk order: Fiber drum or steel drum.
4.What is your delivery term and delivery period?
FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you.The sample within 5 days, and bulk order within 7 days.
5.How to delivery by express?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
8.How to make orders?
A: Send inquiry to us,we do the offer. Payment via Western Union, Moneygram, Bank Account ect.. Then we will arrange shipping. After delivery we will offer tracking No..
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