Usage:
Orally with water.

Dosage:
As directed by the physician.

Shelf life:
36 months

Storage:
Keep in a cool, dry place and protect from light.
Keep out of reach of children.

Pharmacology
As a proton pump inhibitor, it is a fat-soluble weakly basic drug. It is concentrated in an acidic environment and acts specifically on the secretory microtubules formed by the apical membrane of the gastric mucosal wall and the tubular vesicles in the cytoplasm, that is, the site of the proton pump (H+, K+-ATPase) of the gastric wall. And converted into the active form of sulfenamide, irreversible binding to the sulfhydryl group of the proton pump through the disulfide bond, thereby inhibiting the activity of H+, K+-ATPase, blocking the final step of gastric acid secretion, and causing H+ in the parietal cells Can not be transported into the stomach cavity, so that the acid content in the gastric juice is greatly reduced. It has a strong inhibitory effect on gastric acid secretion caused by basal stomach acid and stimulation. It has obvious inhibitory effects on histamine, pentagastrin and vagus nerve-induced gastric acid secretion, and has strong and lasting inhibitory effect on gastric acid secretion caused by dibutyl cyclic adenosine monophosphate which cannot be inhibited by H2 receptor antagonist. After the drug was administered, the amount of gastric acid secretion decreased significantly, and the pH in the stomach increased rapidly. It relieves heartburn and pain faster. The cure rate for duodenal ulcer is also higher, and the recurrence rate is lower.

Indication
1. For gastric ulcer and duodenal ulcer. The two- and three-way regimen of omeprazole combined with antibiotics can be used to treat Helicobacter pylori (HP)-associated peptic ulcers.
2. For reflux esophagitis, gastrinoma (Zhuo-Ai syndrome).
3. Omeprazole intravenous injection can be used for the treatment of acute peptic ulcer bleeding, such as acute gastric mucosal bleeding.

Adverse reactions
1. Can have dry mouth, mild nausea, vomiting, bloating, constipation, diarrhea, abdominal pain, etc.; alanine aminotransferase (ALT), aspartate aminotransferase (AST) and elevated bilirubin also occur Usually mild and short-lived, most do not affect treatment. In addition, foreign data reported that the performance of atrophic gastritis can be observed in the gastric biopsy specimens of patients who have been treated with omeprazole for a long time.
2. Neuropsychiatric system: may have paresthesia, dizziness, headache, lethargy, insomnia, peripheral neuritis and the like.
3. Metabolism/endocrine system: Long-term application of omeprazole can lead to vitamin B12 deficiency.
4. Carcinogenicity: Animal experiments show that omeprazole can cause proliferation of the main endocrine cell-intestinal chromaffin cells in the bottom of the stomach and the stomach, and long-term medication can also cause gastric carcinoid.
5. Others: may have rash, male mammary gland development, hemolytic anemia.

For Export use only