Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock

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Model NO.
Pharmaceutical raw materials
Storage
Cool and Dry
Delivery Time
1-3 Days Against Payment
Shipment
FedEx, TNT, EMS, Epacket, UK USA Domestic Shipping
Price
Negotiable
Package
Discreet Package
Trademark
AIYI
Transport Package
Aluminium Foil Bag, Bottle or Fiber Can
Specification
Medicine Grade
Origin
China
HS Code
3001200010
Model NO.
Pharmaceutical raw materials
Storage
Cool and Dry
Delivery Time
1-3 Days Against Payment
Shipment
FedEx, TNT, EMS, Epacket, UK USA Domestic Shipping
Price
Negotiable
Package
Discreet Package
Trademark
AIYI
Transport Package
Aluminium Foil Bag, Bottle or Fiber Can
Specification
Medicine Grade
Origin
China
HS Code
3001200010

 

Product Name: CYCLAZOSIN HYDROCHLORIDE
Other Name: Cyclazosin Hcl
CAS: 146929-33-1
MF: C23H27N5O4
MW: 473.95

Appearance:White crystal powder

Purity:99%

CYCLAZOSIN HYDROCHLORIDE is A hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride.

Cyclazosin hydrochloride is a hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride. It has a role as an alpha1B-adrenoceptor antagonist. It contains a cyclazosin.

 

  The main indications of Cyclazosin Hydrochloride are acute traumatic brain injury and brain consciousness after the operation. Moreover, Citicoline can treat central nervous system dysfunction and unconsciousness caused by acute injury, paralysis agitans, tinnitus and nerve deafness, and poisoning caused by sleeping pills. In recent years, Citicoline is widely used in clinical for treatment of ischemic stroke, cerebral arteriosclerosis, multiinfarct dementia, Alzheimer's disease, and children viral encephalitis.

 

In Vivo Use Guide 
 
The putative a1B-adrenoceptor antagonist cyclazosin (1mg/kg) in vehicle experiments did not significantly alter the body temperature when compared to vehicle group. The pretreatment of mice with cyclazosin significantly altered the effect of MDMA on core body temperature
Route of Administration: Topical
 
In Vitro Use Guide 
 
Sections of the abdominal aorta, obtained from adult female New Zealand rabbits, were treated with agonists and antagonists of adrenergic receptors. Administration of cyclazosin at a dose of 0.002 μM caused a decrease in the muscle tonus of -0.49 ± 0.10 mN. After blockade of the α1B-adrenergic receptor by 0.02 mkM cyclazosin, the administration of 0.05 μM phenylephrine resulted in an increase of the aortic muscle tonus of 1.49 ± 0.14 mN.

 

Item

Standard

Test Results

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Complies

Crystallinity

meets the requirements.

Complies

Loss on drying

≤2.0%

0.19%

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.1%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.009%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Purity

≥99.0%

99.7%

Assay

99.0%~101.0% (anhydrous substance).

99.8%

Microbiological Analysis

Total plate count

≤1000cfu/g

Complies

Yeast and Moulds

≤100cfu/g

Complies

E. Coli.

Absent

Negative

Salmonella

Absent

Negative

S.aureus

Absent

Negative

Storage

Preserve in well-closed, light-resistant and airtight containers.

Complies


 
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Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
Chinese name: Cellophylcholine Chinese synonym: Cellophylcholine; Cellophylcholine solution, 100PPM English name: CYCLAZOSINHYDROCHLORIDE English synonym: 1- (4-amino-6,7-dimethoxy-2-quinazolinyl) -4- ( 2-furanylcarbonyl) decahydroquinoxaline; Cyclazosinmonohydrochloride; cis-1- (4-Amino-6,7-dimethChemicalbookoxy-2-quinazolinyl) -4- (2-furanylcarbonyl) decahydroquinoxalinemonohydrochloride; CyclazosinhydrochlorideSolution, 100ppmCAS number: 146929-33-1 Molecular formula: C23H27NO Molecular weight: 473.95EINECS No .: Relevant categories: Medical raw materials-; Medical raw materials-; -Mol file: 146929-33-1.mol

Citicoline uses and synthetic methods Indications The main indications are acute brain surgery and conscious disturbances after brain surgery; it is also clinically used for functional and conscious disturbances caused by acute damage to the central nervous system, tremor paralysis, tinnitus and neuropathy Deafness, sleeping pill poisoning, etc .; In recent years, it has been widely used clinically in ischemic stroke, cerebral arteriosclerosis, multi-infarct dementia, dementia, pediatric viral encephalitis and so on. Action Citicoline is a naturally occurring endogenous nucleoside in the body and is an intermediate in the main pathway of cell membrane phospholipid biosynthesis. Nerve cell membrane repair requires a large amount of citicoline. Supplementation of exogenous citicoline can promote the synthesis of phospholipids in nerve cell membranes. Citicoline plays an extremely important role in maintaining a variety of cellular physiology. In many Chemicalbook species, cell membrane dysfunction and degenerative disease caused by ischemia and bleeding, citicoline has a significant clinical therapeutic effect. Use Citicoline can restore the structure of cell membranes after brain cell injury, enhance the function of cell membranes, and improve the function of neurons; 2. Can reduce cerebrovascular resistance, increase cerebral blood flow, promote brain metabolism, improve brain circulation, and improve brain function 3. Increase the secretion of nerve conduction media including acetylcholine and dopamine, enhance the brainstem reticular function related to consciousness, improve the body's state of consciousness, and increase the speed of awakening; 4. It can also inhibit phospholipase A2 Activates to accelerate reabsorption of brain edema. 5. It can promote dopaminergic activity and regulate the physiological function of extrapyramidal system. 6. It has been proven to increase memory and promote learning.

Citicoline (Citicoline, CDP-choline, cytidine-5-diphosphocholine) is a precursor for the synthesis of lecithin, and lecithin is a key component of the cell membrane. When exogenously administered, Citicoline can promote the biosynthesis of lecithin, reduce the destruction of cell membranes, repair the structure of cell membranes, reduce the concentration of free fatty acids, and has obvious neuroprotective effects. In addition, Citicoline can increase the levels of norepinephrine and dopamine in the central nervous system without significant side effects. It is suggested that Citicoline can be used to treat cognitive dysfunction caused by vascular, degenerative and various reasons. Citicoline is administered intravenously, intramuscularly, and orally. Oral absorption is complete, and bioavailability is similar to intravenous drip. Clinical studies on citicoline in the treatment of vascular cognitive dysfunction have been particularly active in recent years. 59 related trials have been retrieved from the literature, including more than 20 foreign literatures.


Citicoline is an intermediate product of phosphatidylcholine biosynthesis. After cerebral ischemia, citicoline increases cell membrane stability, increases glutathione levels, inhibits phospholipid hydrolysis and arachidonic acid production, thereby limiting The production of oxygen free radicals and lipid peroxides. At the same time, the drug can also increase blood flow in the brain, promote energy metabolism in the brain, improve cerebral circulation, and thus play a neuroprotective role.

Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock


Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock

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Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock

 
Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock

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Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
Lab Supply Cyclazosin Hydrochloride CAS 146929-33-1 Citicoline Cdp-Choline in Stock
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