China Pharmaceutical Intermediates/Medicine Raw Materials Febuxostat Intermediate CAS 161798-02-3, Find details about China Medicines Intermediates, Medicines Raw Materials from Pharmaceutical Intermediates/Medicine Raw Materials Febuxostat Intermediate CAS 161798-02-3
Application
The occurrence of gout is caused by excessive production of uric acid in the body and decreased renal clearance ability, accumulation of uric acid in the body, resulting in urate crystals deposition in joints and organs. Therefore, the treatment of gout is usually to promote the excretion of uric acid and inhibit the production of uric acid, and take appropriate measures to improve the relevant symptoms. The production of uric acid in vivo is related to purine metabolism. In the last step of purine metabolism, hypoxanthine generates xanthine under the action of xanthine oxidoreductase (XOR), and then generates uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. Febuxostat, a newly developed XOR inhibitor in the world, reduces uric acid synthesis and concentration in vivo through highly selective action on this oxidase, thus effectively treating ventilation diseases. In the past 30 years, allopurinol is the only drug used to inhibit the production of uric acid in clinical practice, and has been widely used in clinical practice as a gold drug for the treatment of gout, and has made remarkable achievements in the treatment of anti-gout.
Physicochemical properties | |
density | 1.4 + / - 0.1 g/cm3 |
Boiling point | 475.3±55.0 °C at 760 mmHg |
Molecular formula | C14H12N2O3S |
molecular weight | 288.322 |
Flash point | 241.3 + / - 31.5 ° C |
Accurate quality | 288.056854 |
PSA | 111.19000 |
LogP | 4.15 |
Vapor pressure | 0.0± 1.2mmHg at 25°C |
refractive index | 1.629 |
Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.
Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.
Shelf Life: 2 years if sealed and store away from direct sun light.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Delivery time: Around 3-5 workdays after your payment.
1. Any inquiries will be replied within 12 hours.