Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

Function 
 Chlorhexidine gluconate is a germicidal mouthwash that reduces bacteria in the mouth. Chlorhexidine gluconate oral rinse is used to treat gingivitis (swelling, redness, bleeding gums).