Pramoxine hydrochloride is used in the treatment of minor skin disorders. It can relieve pain and pruritus as well as inflammation associated with minor burns and sunburns. Pramoxine is also used to relieve inflammation and pain from insect bites, poison ivy, poison oak, minor cuts and scratches.
Pramoxine hcl,Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development,pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.Pramoxine hcl,Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics,paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranesis thus inhibited, leading to numbness.