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High Quality Tilmicosin Phosphate & Tilmicosin

China High Quality Tilmicosin Phosphate & Tilmicosin, Find details about China Tilmicosin, Tilmicosin Base from High Quality Tilmicosin Phosphate & Tilmicosin

Model NO.
TP
for Animal
Fowl
Function
Antibacterial Drugs
Trademark
Fraken
Transport Package
25kg/Drum
Specification
USP
Origin
China
HS Code
2941909000
Model NO.
TP
for Animal
Fowl
Function
Antibacterial Drugs
Trademark
Fraken
Transport Package
25kg/Drum
Specification
USP
Origin
China
HS Code
2941909000

Tilmicosin phosphate
Tilmicosin is a macrolide antibiotic developed for veterinary use. It is recommended for treatment and prevention of pneumonia in cattle, sheep and pigs, associated with Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms found sensitive to this compound.

 

Tilmicosin phosphate is a macrolide antibiotic synthesized from tylosin, It developed for veterinary use only.and it has an antibacterial spectrum similar to tylosin with enhanced activity against Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms found sensitive to this compound. It is recommended for treatment and prevention of pneumonia in cattle, sheep, poultry and pigs, Not show resistance and cross-resistance with other antibiotic often used in clinic. Mainly used in the Pleuropneumonia and the infection caused by Pasteurellaceae , Pasteurella and mycoplasma.  

 

Specification: 

Product name

Tilmicosin Phosphate

Items

Specification

Appearance

light yellow powder

Identification

IR  complies with CRS

 

Test of assay retention time of peak for sample complies with standard preparation

Water

≤5.0%

PH

5.0-8.0

Trans-Isomer (on dry basis)

12.0-18.0%

Cis-Isomer (on dry basis)

82.0-88.0%

Assay (Tilmicosin)

≥75.0%

 

PHARMACOLOGICAL ACTION

Tilmicosin, (20-deoxo-20-(3,5-dimethylpiperidin-1-yl)-desmycosin) is chemically modified long-acting macrolide antibiotic applied in the veterinary medicine. It is active mainly against Gram-positive and some Gram-negative microorganisms (streptococci, staphylococci, Pasteurella spp., mycoplasmas, etc.). Applied orally in poultry, tilmicosin reaches maximum blood levels after 3 hours and maintains high therapeutic concentrations in the target tissues. It is concentrated in the lungs, penetrating intracellularly in the alveolar macrophages. It is eliminated mainly through feces and urine. Tilmicosin induces no teratogenic and embryotoxic effect.

 

Indication:

For the treatment of bovine respiratory disease (BRD) and ovine respiratory disease (ORD) associated with Mannheimia (Pasteurella) haemolytica. For the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia (Pasteurella) haemolytica.

 

Dosage:

Available formulations of tilmicosin include an injectable for use in cattle and sheep (Micotil 300) and premix formulations for swine (Pulmotil G40, G100 and G200). The recommended dose of the injectable formulation in both cattle and sheep is a single subcutaneous (SC) injection of 10 mg/kg BW. Recommended dose for swine in feed is 200-400 mg/kg of feed for 10 to 21 days, equivalent to 8-20 mg/kg BW per day.

 

Application: Tilmicosin Phosphate is a macrolide antibiotic drug, it is the upgrade product of tylosin phosphate and specially used for veterinary. It is harmfulless, residue free, with strong effection and safety. It mainly cures for the respiratory disease that caused by mycoplasma, animal infective pleuropneumonia that caused by actinobacillus and pasteurella multocida and breast infection of lactational animals. The drug effect is 4 to 8 times than tylosin phosphate. At the same time, it has the advantages of convenient application and less incompatibilities.
Notice:  
1. Forbidden for equus animals, laying hens.
2. Tilmicosin irritates to eyes, it can cause anaphylactic reaction, to avoid direct contact.
3. Forbidden for intravenous injection, the cattle will be died if take intravenous injection of 5mg/kg one time, it also has deadly danger for pigs, quadrumanas and horses.
Shelf life: 2 years

Tilmicosin Base

Chemical name:

Tilmicosin (IUPAC name): (10E, 12E)-(3R,4S,5S,6R,8R,14R,15R)-14-(6-deoxy-2,3-di-O-methyl-b-d-allo-hexopyranosyoxymethyl)-5-(3,6-dideoxy-3-dimethylamino-b-d-gluco-hexapyranosyloxy)-6-[2-(cis-3,5-dimethyl-piperidino)ethyl]-3-hydroxy-4,8,12-trimethyl-9-oxoheptadeca-10,12-dien-15-olide

Chemical Abstracts Services Name: tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-(20(cis: trans))

C.A.S. number: 108050-54-0

Synonyms: 20-Deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin

Molecular formula: C46H80N2O13

Molecular weight: 869.15

OTHER INFORMATION ON IDENTITY AND PROPERTIES

Pure active ingredient:

Melting point: Not determined

Solubility:

Freely soluble (1500 mg/L or greater) in organic solvents (hexane, acetone, acetonitrile, chloroform, dichloromethane, ethyl acetate, methanol, tetrahydrofuran); water solubility is temperature and pH dependent, but is 566 mg/mL at pH 7 and 25°C.

Purity:

Tilmicosin consists of 82-88% cis isomer and 12-18% trans isomer, as determined by liquid chromatographic assay.

 

Tilmicosin Base

USP36

Items

Specification

Appearance

white or almost white powder

Identification

conform

Water

≤5.0%

Cis-Isomer

82.0-88.0%

Trans-Isomer

12.0-18.0%

Total related compound (on anhydrous)

≤10.0%

Individual related compound(on anhydrous)

≤3.0%

Assay(as anhydrous)

≥85.0%

Heavy metal

≤20ppm

Butyl acetate

<0.5%

 

Dosage:

Available formulations of tilmicosin include an injectable for use in cattle and sheep (Micotil 300) and premix formulations for swine (Pulmotil G40, G100 and G200). The recommended dose of the injectable formulation in both cattle and sheep is a single subcutaneous (SC) injection of 10 mg/kg BW. Recommended dose for swine in feed is 200-400 mg/kg of feed for 10 to 21 days, equivalent to 8-20 mg/kg BW per day.

 

Application: Tilmicosin is a macrolide antibiotic drug, it is the upgrade product of tylosin phosphate and specially used for veterinary. It is harmfulless, residue free, with strong effection and safety. It mainly cures for the respiratory disease that caused by mycoplasma, animal infective pleuropneumonia that caused by actinobacillus and pasteurella multocida and breast infection of lactational animals. The drug effect is 4 to 8 times than tylosin phosphate. It has the advantages of convenient application and less incompatibilities simultaneously.
Notice:
1.Tilmicosin formulation can not be injected for swines. 
2. Forbidden for laying hens.
Shelf life: 2 years

Storage Situation: Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Shelf Life: Two years when properly stored.
Delivery: Within two weeks after receiving your prepayment.

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To get more information, just feel free to contact with us. Thanks.
Mr. Liu
Qingdao Fraken International Trading Co., Ltd
Address: RM1005 post mansion yan'an three road, Qingdao, China
 
 
Web: http://fraken.en.made-in-china.com

High Quality Tilmicosin Phosphate & TilmicosinHigh Quality Tilmicosin Phosphate & Tilmicosin

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