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High Purity 99% CAS 120014-06-4 Donepezil Acetylcholinesterase Inhibitor

China High Purity 99% CAS 120014-06-4 Donepezil Acetylcholinesterase Inhibitor, Find details about China Donepezil, 120014-06-4 from High Purity 99% CAS 120014-06-4 Donepezil Acetylcholinesterase Inhibitor

Model NO.
120014-06-4
Shelf Life
Two Years
Trademark
Chenxun
Transport Package
25kg / Drum
Specification
25Kg/ drum
Origin
China
HS Code
2933399090
Model NO.
120014-06-4
Shelf Life
Two Years
Trademark
Chenxun
Transport Package
25kg / Drum
Specification
25Kg/ drum
Origin
China
HS Code
2933399090
Acetylcholinesterase Inhibitor  Donepezil  for Dementia Treatment 120014-06-4
 
Product Description
 

Donepezil
Synonyms:2-[(1-Benzyl-4-Piperidyl)Methyl]-5,6-Dimethoxy-2,3-Dihydroinden-1-One;1-Benzyl-4-[(5,6-Dimethoxy-1-Indanon-2-Yl) Methyl] Piperidine;2,3-Dihydro-5,6-Dimethoxy-2-((1-(Phenylmethyl)-4-Piperidinyl)Methyl)-1h-Inde;n-1-One;n-Benzyl-4-[(5,6-Dimethoxy-1-Indanon-2-Yl)Methyl] Piperidine;5,6-Dimethoxy-2,3-Dihydro-1h-Inden-1-One
CAS: 120014-06-4
MF:C24H29NO3
MW:379.49
Melting point:207°C
Water Solubility:2.931 mg/L

 

Description

 

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.
 

COA

 

TEST ITEMSPECIFICATIONRESULT
AppearanceOff white to white crystalline powderComplies
Solubilityfreely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane		Complies
Identification(1)By IR absorption ,To match with working
standard		Complies
(2) The retention time of the major peak of
the sample should accord with that of the
working standard.		Complies
(3) Test for chlorides. Reponds to the test
for Chlorides.		Complies
PH4.0-7.06.10
Residue on ignition≤0.1%0.03%
Related substanceAny Unkonwn single impurity≤0.3%
Total ≤0.5%		0.04%
0.18%
Heavy metal≤10ppm<10ppm
Residual SolventsMethanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%		Not detected
Not detected
Not detected
Not detected
Not detected
Loss on drying≤0.5%0.20%
AssayOn dried base, C24H29NO3·HCl
should be 98.0% to 102.0%		100.20%
Conclusion: The product complies to Enterprise standard

Product Uses
 
UsageA nootropic. An inhibitor of acetylcholinesterase
UsageA labelled nootropic. An inhibitor of acetylcholinesterase.
UsageAntialzheimer
UsageLabeled Donepezil, intended for use as an internal standard for the quantification of Donepezilby GC- or LC-mass spectrometry.
DefinitionChEBI: Donepezil hydrochloride is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's
disease where it is used to increase cortical acetylcholine.
 

Application


1. Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses.

2. The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. Certainly Alzheimer's disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer's disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain.

3. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

High Purity 99% CAS 120014-06-4 Donepezil Acetylcholinesterase Inhibitor

Packing

· 1kg/aluminium foil bag, with two plastic bags inside.
· 25kg/fiber drum, with two plastic bags inside.
Size:ID 42cm*H52cm,0.08m3/drum;
Net Weight:25kgs Gross Weight:28kgs.
High Purity 99% CAS 120014-06-4 Donepezil Acetylcholinesterase Inhibitor

SHIPPING ADVISE

 By Express
Sultable for under 50kg, Fast:3-4 days. High cost; Door to door service. Easy to plck up the goods.
 By Air
Sultable for more than 50 kg, Fast: 4-5 days, HIgh cost, alrport to alrportprofesslonal broker needed.
 By sea
Sultable for more than 500kg. Slow: 15-45 days, Low cost. Port to Port, protesslonal broker needed.


FAQ

Q1: Can i get small sample?
A: Yes, FREE SAMPLES of some products can be sent on request, but the shipping cost be paid by our customers.
Q2. How to confirm the products quality before placing orders?
A: COA first for you to check the specification,and we test every batch of our product
by HPLC.UV,GC AND TLC AND etc. We also cooperate with independent third party
lab such as SGS,PONY etc.  

Q3: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Money Gram. Also L/C at sight is acceptable for large amount

Why Choose Us
  1. We have 10 years of experience in exporting products, strong market response capabilities and a wide range of trading partners.
  2. We have a variety of certified factories to produce high quality products.
  3. We offer full link hosted services from production to delivery.
  4. We provide testing services prior to shipment of the product.
  5. We will cultivate customers in every country market, let customers develop quickly with us, and win-win cooperation.
  6. Stable supply, delivery on time, quality assurance.

 

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