100% safe customs clearance!!! We will ship by special line that shipping free from custom clearance and deliver to door, No customs problems!Chemical Name:donepezil hydrochloride
Application:antimuscarinic
Donepezil hydrochloride
Molecular Formula:C24H30ClNO3
Formula Weight:415.95
CAS:120011-70-3
Purity:99%
Appearance:white powder
Introduction:
ARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1Hinden- 1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane.
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Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs, compared with similar drugs have a low incidence of adverse reactions and efficacy obvious feature is the only way to reach the U.S. Food and Drug Administration standard treatment guidelines for Alzheimer's disease drug, is the only one species while the FDA approved the listing of new drugs and UK MCA for the treatment of mild to moderate Alzheimer's.
Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs. AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons, such cholinergic theory has been confirmed by histological study.
Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites. Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide, neurotransmitter receptors, or Ca2 + channels.
Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger, it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect, probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.
Product name | Donepezil hydrochloride |
Synonyms | 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride |
CAS No. | 120011-70-3 |
Molecular formula | C24H29NO3.HCl |
Molecular weight | 415.95 |
Specifications |
ITEMS | SPECIFICATIONS | RESULTS |
APPEARANCE | WHITE OR ALMOST WHITE CRYSTALLINE POWDER | CONFORMS |
SOLUBILITY | TO MATCH WORKING STANDARD | CONFORMS |
IDENTIFICATION | 1) BY UV ABSORPTION,TO MATCH WORKING STANDARD 2) BY IR ABSORPTION,TO MATCH WORKING STANDARD | CONFORMS CONFORMS |
PH | 4.0-7.0 | 5.47 |
MELTING POINT | 216-220°C | 218-220°C |
RELATED SUBSTANCE |
TOTAL | ≤1.80% | 0.07% |
SINGLE IMPURITY (UNKNOWN) | ≤0.50% | <0.1% |
LOSS ON DRYING | ≤1.0% | 0.03% |
RESIDUE ON IGNITION | ≤0.10% | 0.08% |
HEAVY METAL | ≤10 PPM | <10 PPM |
ASSAY | ≥99.0% | 99.75% |
CONCLUSION | CONFORMS TO THE ENTERPRISE STANDARD |
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Procaine | 59-46-1 | Bupivacaine | 2180-92-9 |
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Prilocaine | 721-50-6 | Dibucaine hydrochloride | 61-12-1 |
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1st,Good quality:We are a professional manufacturer of chemical raw materials, we have accumulated 16 years of experience in this industry, we guarantee that all products are above 99% purity, of course, we can provide samples for testing, to enhance the trust between us,we believe that you can be more assured to buy from us. 2nd,98% of our products have exported to uk, usa, germany, spain, australia, middle east and many other countries.We get good feedback from our customers on the quality because we have a professional team to monitor the production process in the factory, taking pictures at every important stage and giving feedback to the customers. We have our own factory, so we can control the whole process of the product in our daily work.
3rd,Safe and fast delivery:We provide professional packaging, safe and careful cargo loading experience, we also provide a variety of safe and fast transportation methods for you to choose, 100% Safe Customs Clearance. Q1: Are you a manufacturer?
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MOQ starts from 10g,100g and 1kg.
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Q7: Do you test all your goods before delivery?Yes, our goods will be sent to the laboratory for inspection before being shipped out of the warehouse to ensure that the purity of the products you receive is above 99%.Q8:How to confirm the Product Quality before placing orders?1st, you can get free samples for some products, just pay the basic cost for us.
2nd,Also you can send the specification or your quest to us, we will customize the products for you.
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