Choline chloride carbamate is nonspecific inits action on muscarinic receptor subtypes. The pharmacologicalactivity of carbachol is similar to that of ACh. It isan ester of choline and thus possesses both muscarinic andnicotinic properties by cholinergic receptor stimulation. Itcan also act indirectly by promoting release of ACh and byits weak anticholinesterase activity.It can be supplied to tissue culture media, animal feed additive and used in clinical anti-fatty liver agent.
It can be used for treating fatty liver and cirrhosis. It can also be used as the feed additive which is capable of stimulating ovaries for giving birth to more eggs and farrowing. It can also facilitate the weight gaining process of livestock, fish, etc.
Choline chloride is effective in the prevention and treatment of the fat deposition and tissue degeneration in the organs of livestock and poultry. It can also promote the absorption and synthesis of amino acids. Moreover, it can enhance physical fitness and disease resistance of livestock, promote their growth and development, and improve poultry laying rate. The usage amount is 1-2 g/kg.
As a kind of feed additive, choline chloride has the following physiological effects: it can prevent the accumulation of the fat in liver and the kidney and tissue degeneration; it can promote recombination of amino acids; it can improve the utilization efficiency of amino acids, especially the essential amino acid methionine in vivo. In Japan, 98% of the applied choline chloride is used as the feed additives of chickens, pigs, cattle and fish and other animal. Most of them have been processed into powder; the preparation process of 50% powder is that: first add an appropriate excipient of certain particle size into the mixer is prepared by previously adding an appropriate particle size of the excipient, and then add drop wise of aqueous solution of choline chloride, after mixing, drying to derive it. Some powder products are also blended with vitamins, minerals, and drugs. Choline chloride is the vitamin B-class drug which can be used for the treatment of hepatitis, liver function degradation, early cirrhosis, and pernicious anemia.