Vitamin Chemical Materials Pharmaceutical Chemical Low Price Yk11 Skin Care Gw/ 501516 CAS 317318-70-0
China Vitamin Chemical Materials Pharmaceutical Chemical Low Price Yk11 Skin Care Gw/501516 CAS 317318-70-0, Find details about China 99% Purity, Chemical Materials from Vitamin Chemical Materials Pharmaceutical Chemical Low Price Yk11 Skin Care Gw/501516 CAS 317318-70-0
| Product Name | GW-501516 |
| Synonyms | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]aceticacid;GW-501516,>=98%;ENDUROBOL(GW-501516)/CARDARINE/;Cardarine(GW-501516,GSK-516);GW-501615;CB646Chemicalbook5728;2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetica;{2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-aceticacid |
| CAS NO | 317318-70-0 |
| Molecular Formula | C21H18F3NO3S2 |
| Molecular Weight | 453.5 |
| Melting point | 134-136°C |
| Boiling Point | 584.5±60.0 °C at 760 mmHg |
| Flash Point | 307.3±32.9 °C |
| Density | 1.4±0.1 g/cm3 |
| Purity | ≥97% |
| Grade | Pharmaceutical Grade |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | white to beige powder |
| Storage | Store at dry and cool place |
| Packing and Shipping | Packing: Drum / Aluminum Foil Bag / According to customer's requiement Shipping: 3-5 working days after receive payment, by Fedex,UPS,EMS,DHL,Sea and air transport |
| Usage | It is the best in terms of endurance, energy, endurance and any type of performance improvement |
Description:
GW-501516 (also known as GW-501,516, GW-1516, GSK-516, Cardarine, is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. It entered into clinical development as a drug candidate for metabolic and cardiovascular diseases.
Exercise can increase peroxisome proliferator-activated receptor-δ (PPARδ) expression in skeletal muscle. PPARδ regulates muscle metabolism and reprograms muscle fibre types to enhance running endurance. This study utilized metabolomic profiling to examine the effects of GW-501516, a PPARδ agonist, on running endurance in mice.
Reference:
1. Koh B (2013-03-22). "Anti-doping agency warns cheats on the health risks of Endurobol". The Conversation.
2. Sahebkar A, Chew GT, Watts GF (March 2014). "New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease". Expert Opinion on Pharmacotherapy. 15 (4): 493-503. doi:10.1517/14656566.2014.876992. PMID 24428677. S2CID 21158696. Despite these promising early results, the further investigation and development of GW-501516 was discontinued after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes
3. "GW-501516 GlaxoSmithKline, Ligand milestone payment". R & D Focus Drug News. 28 June 2004.
4. Wolf G (November 2003). "The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis". Nutr. Rev. 61 (11): 387-90. doi:10.1301/nr.2003.nov.387-390. PMID 14677574. S2CID 12362203.
5. Oliver WR, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM (April 2001). "A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport". Proc. Natl. Acad. Sci. U.S.A. 98 (9): 5306-11. Bibcode:2001PNAS...98.5306O. doi:10.1073/pnas.091021198. PMC 33205. PMID 11309497.
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Wuhan wingroup Chemicals customers have expanded to North America, Europe, India, and we are constantly exploring and working hard.
Companies adhering to the concept of scientific and technological innovation, green environmental protection, honest and trustworthy, and common development, dedicated to provide customers at home and abroad with reasonable prices, quality products and professional technical services.
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4. After years export shipping experience, with professional and experienced cooperated forwarders,we ensure that goods can be delivered in multiple ways safetly and efficiently.
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A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
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A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.
Q7:Do you test all your goods before delivery?
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