China High Quality Gw0742 Powder CAS 317318-84-6, Find details about China Gw0742, 317318-84-6 from High Quality Gw0742 Powder CAS 317318-84-6
What is GW 0742
GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.
Name | GW-0742 |
Synonyms | [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid; GW-610742; GW-0742X; |
C.A.S NO. | 317318-84-6 |
Density | 1.462g/cm3 |
Molecular formula | C21H17F4NO3S2 |
Molecular weight | 471.48800 |
pKa | 3.17±0.10(Predicted) |
Solubility | DMSO: >5 mg/mL |
Melting point | 134.5-135.5 °C |
Flashing point | 311.514ºC |
Boiling point | 591.476ºC at 760 mmHg |
Function:
GW 0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .
GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.
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