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Product Name | Tilmicosin |
Appearance | white or yellowish powder |
CAS No | 108050-54-0 |
MF | C46h80n2o13.H3po4 |
Type | Antibiotic and Antimicrobial Agents |
Morre Infors | Tilmicosin is a broad-spectrum semi-synthetic bactericidal macrolide antibiotic synthesized from tylosin. It has an antibacterial spectrum that is predominantly effective against Mycoplasma, Pasteurella and Haemophilus spp. and various Gram-positive organisms such as Corynebacterium spp. It is believed to affect bacterial protein synthesis through binding to 50S ribosomal subunits. Cross-resistance between tilmicosin and other macrolide antibiotics has been observed. Following oral administration, tilmicosin is excreted mainly via the bile into the faeces, with a small proportion being excreted via the urine. |
Analysis Item | Standard | Test results | |||
Appearance | Type white to yellow powder | Pale yellow powder | |||
Solubility | Soluble in water, no visible evidence of contamination of foreign matter | Conforms | |||
Identification | IR spectra is consistent with CRS. | Conforms | |||
The retention time of the major peak of the assay preparation corresponds to that of the standard preparation, as obtained in the assay. | Conforms | ||||
Positive in phosphate test | Conforms | ||||
PH | 5.0~8.0 | 7.6 | |||
Water | ≤5.0% | 1.2% | |||
Cis-Isomer | 82.0%~88.0% | 86.1% | |||
Trans-Isomer | 12.0%~18.0% | 13.9% | |||
Residue on Ignition | ≤5.0% | 2.0% | |||
Heavy Metal | ≤30PPM | Conforms | |||
Assay | ≥98.0% (Tilmicosin assay dried) | 98.8% | |||
Conclusion | Complies with the requirements of USP39,EP Standard. |