Description :

Follistati is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.

Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 95.0%
Formulation: Lyophilized from a concentrated (1mg/ml) solution containing no additives. Solubility: It is recommended to reconstitute the lyophilized Follistati in sterile 18M -cm H2O not less than 100 G/ml, which can then be further diluted to other aqueous solutions. Stability: Lyophilized Follistati although stable at room temperature for 3 weeks, should be stored desiccated below -18ºC. Upon reconstitution FST should be stored at 4ºC between 2-7 days and for future use below -18ºC. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).


Follistati (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistati cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistati domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistati is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistati can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistati is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistati is a 37.8 kDa protein containing 344 amino acids .