Factory Supply Chemical/Pharmaceutical API CAS 209860-87-7 Tafluprost
China Factory Supply Chemical/Pharmaceutical API CAS 209860-87-7 Tafluprost, Find details about China R-161 from Factory Supply Chemical/Pharmaceutical API CAS 209860-87-7 Tafluprost
Basic Info.
Common Name
Tafluprost
CAS Number
209860-87-7
Molecular Weight
452.531
Density
1.2±0.1 g/cm3
Boiling Point
552.9±50.0 °c at 760 Mmhg
Molecular Formula
C25h34f2o5
Flash Point
288.2±30.1 °c
Specification
g/bottle, g/bag
Origin
China
Common Name
Tafluprost
CAS Number
209860-87-7
Molecular Weight
452.531
Density
1.2±0.1 g/cm3
Boiling Point
552.9±50.0 °c at 760 Mmhg
Molecular Formula
C25h34f2o5
Flash Point
288.2±30.1 °c
Specification
g/bottle, g/bag
Origin
China
Product Desciption
Product Description:
Product Name: AFP-168 CAS NO: 209860-87-7
Synonyms:
propan-2-yl(Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate;
Taflotan;
Tafluprost;
Chemical & Physical Properties:
Appearance: Pale yellow thick oil
Assay :≥99.00%
Density: 1.186 g/cm3
Boiling Point: 552.9ºC at 760mmHg
Flash Point: 288.2ºC
Refractive Index: 1.548
Vapor Pressure: 4.62E-13mmHg at 25ºC
Tafluprost is a novel prostanoid used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula. Glaucoma is second only to cataracts as a causative factor of blindness. By 2010, it is estimated that approximately 60 million people worldwide will be afflicted by glaucoma, so effective treatments should garner a large market. PG analogs have been widely used for lowering IOP by increasing uveoscleral outflow through agonism of the prostanoid FP receptor, and currently marketed versions include latanoprost, unoprostone isopropyl ester, bimatoprost, and travoprost. Compared to the carboxylic acid of latanaprost (Ki=4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki=0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative.
Compared to the carboxylic acid of latanaprost (Ki 4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki 0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative. The bottom appendage is then completed by the fluorination of the ketone with morpholino-sulfur trifluoride. Hydrolysis of the benzoate ester protecting group liberates the hydroxy group, and reduction of the lactone is accomplished with aluminum hydride to generate the lactol. Condensation of this intermediate with the phosphonium salt of the acid side chain generates the free acid, or active ingredient, which is subsequently esterified with 2-iodopropan in the presence of DBU.
If you are interested in our products or have any questions, please feel free to contact us!
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
Quality Assurance:
COA will be provided before making payment.
Product standards strictly complies to COA.
If any quality problem verified , 100% replace product or return payment.
If still feel worried, sample can be provided.
FAQ:
Q1. What's the MOQ?
A: It is based on the different product. Some are 1g and some are 1 ton. Plesae be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 10 days to you.
Q3. If I need less than the MOQ, is it possible.
A: Yes. If less than MOQ. the price will be 5% more than the MOQ. It based on the different product. Plesae be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Plesae be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, west union, money gram, order online.
Our services:
1) One to one business communication.
2) Any inquiries will be replied within 12 hours.
3) We offer convenient one-station purchasing service.Our professionaland thoughtful after-sales service eliminates your worries.
4) We has 10 years' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
5) OEM/ODM Available.
6) Reasonable & competitive price, fast lead time.
7) Sample is available for your evaluation & Formulation development.
8) Faster delivery: Sample order in stock and 3-5 workdays for bulk production.
9) Excellent after-sale service.
Packaging & Delivery:
Product Name: AFP-168 CAS NO: 209860-87-7
Synonyms:
propan-2-yl(Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate;
Taflotan;
Tafluprost;
Chemical & Physical Properties:
Appearance: Pale yellow thick oil
Assay :≥99.00%
Density: 1.186 g/cm3
Boiling Point: 552.9ºC at 760mmHg
Flash Point: 288.2ºC
Refractive Index: 1.548
Vapor Pressure: 4.62E-13mmHg at 25ºC
Tafluprost is a novel prostanoid used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula. Glaucoma is second only to cataracts as a causative factor of blindness. By 2010, it is estimated that approximately 60 million people worldwide will be afflicted by glaucoma, so effective treatments should garner a large market. PG analogs have been widely used for lowering IOP by increasing uveoscleral outflow through agonism of the prostanoid FP receptor, and currently marketed versions include latanoprost, unoprostone isopropyl ester, bimatoprost, and travoprost. Compared to the carboxylic acid of latanaprost (Ki=4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki=0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative.
Compared to the carboxylic acid of latanaprost (Ki 4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki 0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative. The bottom appendage is then completed by the fluorination of the ketone with morpholino-sulfur trifluoride. Hydrolysis of the benzoate ester protecting group liberates the hydroxy group, and reduction of the lactone is accomplished with aluminum hydride to generate the lactol. Condensation of this intermediate with the phosphonium salt of the acid side chain generates the free acid, or active ingredient, which is subsequently esterified with 2-iodopropan in the presence of DBU.
If you are interested in our products or have any questions, please feel free to contact us!
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
Quality Assurance:
COA will be provided before making payment.
Product standards strictly complies to COA.
If any quality problem verified , 100% replace product or return payment.
If still feel worried, sample can be provided.
FAQ:
Q1. What's the MOQ?
A: It is based on the different product. Some are 1g and some are 1 ton. Plesae be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 10 days to you.
Q3. If I need less than the MOQ, is it possible.
A: Yes. If less than MOQ. the price will be 5% more than the MOQ. It based on the different product. Plesae be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Plesae be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, west union, money gram, order online.
Our services:
1) One to one business communication.
2) Any inquiries will be replied within 12 hours.
3) We offer convenient one-station purchasing service.Our professionaland thoughtful after-sales service eliminates your worries.
4) We has 10 years' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
5) OEM/ODM Available.
6) Reasonable & competitive price, fast lead time.
7) Sample is available for your evaluation & Formulation development.
8) Faster delivery: Sample order in stock and 3-5 workdays for bulk production.
9) Excellent after-sale service.
Packaging & Delivery:
| Packing : | 1kg/bag ,25kg/bag;25kg/drum; according to your requirements |
| Port: | Shanghai/Tianjin/Dalian/Beijing/Xi'an |
| Lead Time : | 3-5 working days upon received the payment |
| For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. | |
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