TRH, also frequently referred to as Protirelin, is a small peptide hormone produced in the hypothalamus. Its main functions are to stimulate the release of both thyroid-stimulating hormone and prolactin from the anterior pituitary. TRH is used clinically to test the function of the anterior pituitary gland in the work-up of thyroid disorders. Research shows that TRH has anti-depressant and anti-suicidal properties. It also likely plays roles in regulating the aging process, arousal, feeding behavior, autonomic regulation,and fighting free radical damage.


Thyrotropin Releasing Hormone (TRH) Walter Pierpaoli, MD, PhD Interbion Foundation for Basic Biomedical Research (TRH Absrtact):Previous work from our laboratory prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. In addition, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations.