GMP Factory Supply Saxagliptin Hydrate API CAS 945667-22-1
China GMP Factory Supply Saxagliptin Hydrate API CAS 945667-22-1, Find details about China Saxagliptin Hydrate, Onglyza from GMP Factory Supply Saxagliptin Hydrate API CAS 945667-22-1
Basic Info.
Model NO.
R-296
Common Name
Saxagliptin Hydrate
CAS Number
945667-22-1
Molecular Weight
333.425
Molecular Formula
C18h27n3o3
Transport Package
Bag, Drum
Specification
1kg/bag, 25kgs/drum
Origin
China
HS Code
2933990090
Model NO.
R-296
Common Name
Saxagliptin Hydrate
CAS Number
945667-22-1
Molecular Weight
333.425
Molecular Formula
C18h27n3o3
Transport Package
Bag, Drum
Specification
1kg/bag, 25kgs/drum
Origin
China
HS Code
2933990090
Product Desciption
Product Description:
Product Name: Saxagliptin hydrate API CAS 945667-22-1
Synonyms:
Chemical & Physical Properties:
Appearance : White powder
Assay : No less than 99.5%
Safety Information:
HS Code: 2933990090
Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.IC50 value: 26 nM [1]Target: DPP4in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and <250-fold, respectively, compared with DPP8 and DPP9). Saxagliptin reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion.in vivo: Saxagliptin is highly effective at eliciting marked dose-dependent enhancements in glucose clearance in the dose range 0.13-1.3 mg/kg in ob/ob mice relative to controls. Saxagliptin dose-dependently elevate plasma insulin significantly at 15 min post-oGTT, with concomitant improvement in the glucose clearance curves at 60 min post-oGTT.
Our factory manufacture's Saxagliptin CAS 361442-04-8, mature technology, stable output, quality assurance.
Inventory Status : In Stock.
We can provide Saxagliptin hydrate API CAS 945667-22-1 certificate of analysis( COA), Saxagliptin hydrate API CAS 945667-22-1 MOA, ROS, MSDS and other support for you !
If you are interested in our products or have any questions, please feel free to contact us!
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
Quality Assurance:
COA will be provided before making payment.
Product standards strictly complies to COA.
If any quality problem verified , 100% replace product or return payment.
If still feel worried, sample can be provided.
FAQ:
Q1. What's the MOQ?
A: It is based on the different product. Some are 1g and some are 1 ton. Plesae be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 10 days to you.
Q3. If I need less than the MOQ, is it possible.
A: Yes. If less than MOQ. the price will be 5% more than the MOQ. It based on the different product. Plesae be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Plesae be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, west union, money gram, order online.
Our services:
1) One to one business communication.
2) Any inquiries will be replied within 12 hours.
3) We offer convenient one-station purchasing service.Our professionaland thoughtful after-sales service eliminates your worries.
4) We has 10 years' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
5) OEM/ODM Available.
6) Reasonable & competitive price, fast lead time.
7) Sample is available for your evaluation & Formulation development.
8) Faster delivery: Sample order in stock and 3-5 workdays for bulk production.
9) Excellent after-sale service.
Packaging & Delivery:
Product Name: Saxagliptin hydrate API CAS 945667-22-1
Synonyms:
| saxagliptin hydrate |
| Onglyza |
| (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate (1:1) |
| UNII:9GB927LAJW |
| saxagliptin |
| saxagliptin monohydrate |
| (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile,hydrate |
| 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)acetyl]-, (1S,3S,5S)-, hydrate (1:1) |
| Saxagliptin (hydrate) |
Chemical & Physical Properties:
Appearance : White powder
Assay : No less than 99.5%
Safety Information:
HS Code: 2933990090
Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.IC50 value: 26 nM [1]Target: DPP4in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and <250-fold, respectively, compared with DPP8 and DPP9). Saxagliptin reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion.in vivo: Saxagliptin is highly effective at eliciting marked dose-dependent enhancements in glucose clearance in the dose range 0.13-1.3 mg/kg in ob/ob mice relative to controls. Saxagliptin dose-dependently elevate plasma insulin significantly at 15 min post-oGTT, with concomitant improvement in the glucose clearance curves at 60 min post-oGTT.
Our factory manufacture's Saxagliptin CAS 361442-04-8, mature technology, stable output, quality assurance.
Inventory Status : In Stock.
We can provide Saxagliptin hydrate API CAS 945667-22-1 certificate of analysis( COA), Saxagliptin hydrate API CAS 945667-22-1 MOA, ROS, MSDS and other support for you !
If you are interested in our products or have any questions, please feel free to contact us!
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
Quality Assurance:
COA will be provided before making payment.
Product standards strictly complies to COA.
If any quality problem verified , 100% replace product or return payment.
If still feel worried, sample can be provided.
FAQ:
Q1. What's the MOQ?
A: It is based on the different product. Some are 1g and some are 1 ton. Plesae be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 10 days to you.
Q3. If I need less than the MOQ, is it possible.
A: Yes. If less than MOQ. the price will be 5% more than the MOQ. It based on the different product. Plesae be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Plesae be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, west union, money gram, order online.
Our services:
1) One to one business communication.
2) Any inquiries will be replied within 12 hours.
3) We offer convenient one-station purchasing service.Our professionaland thoughtful after-sales service eliminates your worries.
4) We has 10 years' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
5) OEM/ODM Available.
6) Reasonable & competitive price, fast lead time.
7) Sample is available for your evaluation & Formulation development.
8) Faster delivery: Sample order in stock and 3-5 workdays for bulk production.
9) Excellent after-sale service.
Packaging & Delivery:
| Packing : | 1kg/bag ,25kg/bag;25kg/drum; according to your requirements |
| Port: | Shanghai/Tianjin/Dalian/Beijing/Xi'an |
| Lead Time : | 3-5 working days upon received the payment |
| For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. | |
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