Valsartan Capsules for Moderate Hypertension
China Valsartan Capsules for Moderate Hypertension, Find details about China Valsartan Capsules, Ace Inhibitor Intolerance from Valsartan Capsules for Moderate Hypertension
Basic Info.
Model NO.
FC0100
Model NO.
FC0100
Product Desciption
Item Name:valsartan capsules
Molecular formula:C24H29N5O3
Item Description
Item nanme:valsartan capsules
Item character:The product is whie
Indication:
Valsartan is suitable for all kinds of mild to moderate hypertension, especially for patients who do not tolerate ACE inhibitors.
Item specifications: 80mg*28tab/box
Usage and dosage:The recommended dose is 80 mg once daily, regardless of gender, age and race. The antihypertensive effect appeared within 2 weeks and reached the maximum after 4 weeks. If the blood pressure can not be controlled sufficiently, the daily dose can be increased to 160 mg or diuretics added. It can be used with other antihypertensive agents.
There is no need to adjust the dosage for patients with mild to moderate renal injury or non biliary and non cholestasis liver dysfunction.
There is no need to adjust the dose in elderly patients.
There is no data on the safety and efficacy of the drug in children.
Patients with hypertension take this medicine, in the blood pressure drop at the same time does not affect the heart rate.
When the drug is stopped suddenly, there will be no blood pressure rebound and other clinical adverse reactions.
There was no significant effect on total cholesterol, fasting triglyceride, fasting blood glucose and uric acid after multi dose administration.
Adverse reactions
The overall adverse reactions of the drug were similar to those in the placebo group. The adverse reactions observed in clinical application are headache, dizziness, virus infection, upper respiratory tract infection, cough, diarrhea, fatigue, rash, rhinitis, back pain, nausea, pharyngitis and joint pain. The incidence of adverse reactions was not related to dose and treatment time, gender, age or race. It was not known whether the adverse reactions had causal relationship with the treatment of this product.
Test index:
This medicine can cause hemoglobin and hematocrit to decrease. In the clinical control trial, the hematocrit and hemoglobin of the patients taking the drug were significantly reduced, 0.8% and 0.4% respectively, and 0.1% in the placebo group.
The patients with neutropenia were 1.9% and 1.8% respectively.
In the clinical control trial, the patients who took the drug had significant increase in serum creatinine, potassium and total bilirubin were 0.8%, 4.4% and 6%, respectively, while ACE inhibitor group was 1.6%, 6.4% and 12.9%, respectively.
The liver function index of patients taking this medicine increased occasionally.
The special laboratory indexes need not be monitored when the drug is used in the treatment of essential hypertension.
Taboo:
It is forbidden for those who are allergic to this product; It is forbidden for pregnant and lactating women.
Matters needing attention:
1. Patients with hyponatremia or hypovolemia:
Symptomatic hypotension may occur when starting treatment with valsartan in patients with severe sodium deficiency and / or hypovolemia (e.g. due to high-dose diuretics). Therefore, hyponatremia or hypovolemia should be corrected before using this drug.
If hypotension occurs, the patient must lie on his back and use normal saline for intravenous injection if necessary. Transient hypotension does not prevent further treatment, so once blood pressure is stable, treatment can be continued.
2. Patients with liver function damage:
About 70% of valsartan was excluded from bile in its original form; Valsartan does not undergo biotransformation, so its systemic effect has nothing to do with liver dysfunction; However, the clearance rate of valsartan in patients with biliary cirrhosis or biliary obstruction is lower (AUCs is higher), so these patients should be cautious when taking valsartan.
3. Patients with renal function impairment:
Since the renal clearance rate of valsartan accounts for only 30% of the total plasma clearance rate, there is no relationship between its systemic effects and renal function. There is no need to adjust the dosage of Valsartan for patients with renal insufficiency.
After inhibition of renin angiotensin aldosterone system, renal function may be changed in sensitive patients. For patients whose renal function depends on the activity of renin angiotensin aldosterone system (such as patients with severe congestive heart failure), treatment with angiotensin converting enzyme inhibitors or angiotensin receptor antagonists may lead to oliguria and / or progressive azotemia and (rare) acute renal failure and / or death. Therefore, patients with severe renal insufficiency (creatinine clearance rate < 10ml / min) should be treated with caution.
12 patients with renal hypertension caused by unilateral renal artery stenosis had no significant changes in renal hemodynamics, serum creatinine or blood urea nitrogen after short-term administration of valsartan. Long term use of valsartan has not been studied in patients with unilateral or bilateral renal artery stenosis. Because the drugs that affect the renin angiotensin aldosterone system may increase the serum creatinine or blood urea nitrogen in patients with unilateral or bilateral renal artery stenosis, it is necessary to monitor these indexes for safety.
4. No mutagenic, mitogenic or carcinogenic effects have been found.
5. Don't keep the medicine out of the reach of children.
6. Waste drug packaging should not be discarded at will.
Medication for pregnant and lactating women:
Disabled.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
Molecular formula:C24H29N5O3
Item Description
Item nanme:valsartan capsules
Item character:The product is whie
Indication:
Valsartan is suitable for all kinds of mild to moderate hypertension, especially for patients who do not tolerate ACE inhibitors.
Item specifications: 80mg*28tab/box
Usage and dosage:The recommended dose is 80 mg once daily, regardless of gender, age and race. The antihypertensive effect appeared within 2 weeks and reached the maximum after 4 weeks. If the blood pressure can not be controlled sufficiently, the daily dose can be increased to 160 mg or diuretics added. It can be used with other antihypertensive agents.
There is no need to adjust the dosage for patients with mild to moderate renal injury or non biliary and non cholestasis liver dysfunction.
There is no need to adjust the dose in elderly patients.
There is no data on the safety and efficacy of the drug in children.
Patients with hypertension take this medicine, in the blood pressure drop at the same time does not affect the heart rate.
When the drug is stopped suddenly, there will be no blood pressure rebound and other clinical adverse reactions.
There was no significant effect on total cholesterol, fasting triglyceride, fasting blood glucose and uric acid after multi dose administration.
Adverse reactions
The overall adverse reactions of the drug were similar to those in the placebo group. The adverse reactions observed in clinical application are headache, dizziness, virus infection, upper respiratory tract infection, cough, diarrhea, fatigue, rash, rhinitis, back pain, nausea, pharyngitis and joint pain. The incidence of adverse reactions was not related to dose and treatment time, gender, age or race. It was not known whether the adverse reactions had causal relationship with the treatment of this product.
Test index:
This medicine can cause hemoglobin and hematocrit to decrease. In the clinical control trial, the hematocrit and hemoglobin of the patients taking the drug were significantly reduced, 0.8% and 0.4% respectively, and 0.1% in the placebo group.
The patients with neutropenia were 1.9% and 1.8% respectively.
In the clinical control trial, the patients who took the drug had significant increase in serum creatinine, potassium and total bilirubin were 0.8%, 4.4% and 6%, respectively, while ACE inhibitor group was 1.6%, 6.4% and 12.9%, respectively.
The liver function index of patients taking this medicine increased occasionally.
The special laboratory indexes need not be monitored when the drug is used in the treatment of essential hypertension.
Taboo:
It is forbidden for those who are allergic to this product; It is forbidden for pregnant and lactating women.
Matters needing attention:
1. Patients with hyponatremia or hypovolemia:
Symptomatic hypotension may occur when starting treatment with valsartan in patients with severe sodium deficiency and / or hypovolemia (e.g. due to high-dose diuretics). Therefore, hyponatremia or hypovolemia should be corrected before using this drug.
If hypotension occurs, the patient must lie on his back and use normal saline for intravenous injection if necessary. Transient hypotension does not prevent further treatment, so once blood pressure is stable, treatment can be continued.
2. Patients with liver function damage:
About 70% of valsartan was excluded from bile in its original form; Valsartan does not undergo biotransformation, so its systemic effect has nothing to do with liver dysfunction; However, the clearance rate of valsartan in patients with biliary cirrhosis or biliary obstruction is lower (AUCs is higher), so these patients should be cautious when taking valsartan.
3. Patients with renal function impairment:
Since the renal clearance rate of valsartan accounts for only 30% of the total plasma clearance rate, there is no relationship between its systemic effects and renal function. There is no need to adjust the dosage of Valsartan for patients with renal insufficiency.
After inhibition of renin angiotensin aldosterone system, renal function may be changed in sensitive patients. For patients whose renal function depends on the activity of renin angiotensin aldosterone system (such as patients with severe congestive heart failure), treatment with angiotensin converting enzyme inhibitors or angiotensin receptor antagonists may lead to oliguria and / or progressive azotemia and (rare) acute renal failure and / or death. Therefore, patients with severe renal insufficiency (creatinine clearance rate < 10ml / min) should be treated with caution.
12 patients with renal hypertension caused by unilateral renal artery stenosis had no significant changes in renal hemodynamics, serum creatinine or blood urea nitrogen after short-term administration of valsartan. Long term use of valsartan has not been studied in patients with unilateral or bilateral renal artery stenosis. Because the drugs that affect the renin angiotensin aldosterone system may increase the serum creatinine or blood urea nitrogen in patients with unilateral or bilateral renal artery stenosis, it is necessary to monitor these indexes for safety.
4. No mutagenic, mitogenic or carcinogenic effects have been found.
5. Don't keep the medicine out of the reach of children.
6. Waste drug packaging should not be discarded at will.
Medication for pregnant and lactating women:
Disabled.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
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