Factory Supply High Quality Fluocinolone acetonide Powder CAS. 67-73-2  99% Purity

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical coricosteroids is unclear. Various laboratory method, including vasoconstrictor assays, are used to compare and predict potencies and clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognize correlation exists between vasoconstrictor potency and the therapeutic efficacy in man.