Estradiol  is used in form of an ethanolic solution for topical application on the scalp. Similarly to other drugs against alopecia, topical or oral, it has to be applied continuously to prevent further hair loss.Regrowth of hair that was already lost is only possible to a limited extent. In general, advanced alopecia does not respond well to medical treatment, which is thought to be a consequence of the hair roots being lost.
As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.

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