China Good Quality Antidepressant Drug Agomelatine CAS 138112-76-2 Agomelatine Powder, Find details about China Nootropics Nad+, Anti-Depressant from Good Quality Antidepressant Drug Agomelatine CAS 138112-76-2 Agomelatine Powder
Product Name | Agomelatine |
Appearance | White Powder |
Purity | 99% |
CAS No | 138112-76-2 |
MF | C15h17no2 |
MW | 243.301 |
Agomelatine has shown antidepressant effects in a variety of animal models of depression.The mechanism of antidepressant may be related to the increase of neuronal plasticity and neuronal proliferation in hippocampus.
Immunostaining was used to measure the proliferation, regeneration and death of nerve cells in the brain of adult rats. It was found that long-term (3 weeks) administration of agomelatine increased the proliferation and regeneration of neurons in the ventral dentate gyrus of the hippocampus, which is involved in emotional response.No similar effect was observed at acute or subacute administration (4 h or 9 weeks).
After prolonged administration, the whole dentate gyrus region showed cell proliferation and neuronal regeneration, suggesting that agomelatine can increase the nerve regeneration in hippocampus to some extent, thus generating new granulosa cells.
Application
Agomelatine is indicated for the treatment of major depressive episodes in adults. Ten placebo controlled trials have been performed to investigate the short term efficacy of agomelatine in major depressive disorder. At the end of treatment, significant efficacy was demonstrated in six of the ten short- term double-blind placebo-controlled studies. Two were considered "failed" trials, as comparators of established efficacy failed to differentiate from placebo. Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies. The maintenance of antidepressant efficacy was demonstrated in a relapse prevention study.
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T estoste Blend / Sustan250 | D ehydroepiandrostero |
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B olde Acetat | O xymetho / Anadr |
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M ethenolo Acetat / Primobo Acetat | A nastro / Arimi |
M ethenolo Enanthat / Primobol Enanthat | E xemest /Aromas |
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