Cas 317318-84-6 Powerful SAMRs Steroids Powder Gw 0742 Gw610742 For Obesity Treatment

Cas 317318-84-6 Powerful SAMRs Steroids Powder Gw 0742 Gw610742 For Obesity Treatment

Cas 317318-84-6 Powerful SAMRs Steroids Powder Gw 0742 Gw610742 For Obesity Treatment

 

 

 

gw-0742 brief introduction

1. name: gw-0742

2. other name: gw610742

3. cas: 317318-84-6

4. molecular formula:c21h17f4no3s2

5. formula weight:471.5

6. appearance:white solid

7. mp:134.5-135.5 °c

8.category:srm steroid
 

gw-0742 description:
 

1. gw0742 is a high affinity ppar-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.

2. a high throughput screening campaign was conducted to identify small molecules with the ability to inhibit

3. the interaction between the vitamin d receptor (vdr) and steroid receptor coactivator.

4. these inhibitors represent novel molecular probes to modulate gene regulation mediated by vdr. the peroxisome proliferator-activated receptor δ (pparδ) agonist gw0742 was among the identified vdr-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µm.

5. the highest antagonist activity for gw0742 was found for vdr and the androgen receptor (ar). surprisingly, gw0742 behaved as ppar agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.

 

6. a unique spectroscopic property of gw0742 was identified as well. in the presence of rhodamine-derived molecules, gw0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

7. the gw0742-inhibited nr-coactivator binding resulted in a reduced expression of five different nr target genes in lncap cells in the presence of agonist. especially vdr target genes cyp24a1, igfbp-3 and trpv6 were negatively regulated by gw0742.

 

8. gw0742 is the first vdr ligand inhibitor lacking the secosteroid structure of vdr ligand antagonists. nevertheless, the vdr-meditated downstream process of cell differentiation was antagonized by gw0742 in hl-60 cells that were pretreated with the endogenous vdr agonist 1,25-dihydroxyvitamin d3.

 

there are two main uses with gw-0742.

1.the first and most common use is that of increased endurance. gw0742 has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. anyone want a drastic increase in endurance will find that gw truly shines in this aspect. it takes effect very quickly and the results can be staggering. a common dose of 10 mg day will provide a significant increase in endurance.

2.the second common usage with gw0742 is that of fat loss. many users turn to gw as it has shown to melt off fat while still being non-catabolic. you will find that you can still hold on to some muscle as you are losing fat. it helps when you are running it in conjunction with sars ostaine and s4, to hold on to as much muscle as possible. a dosage of 10 mg a day will provide good amounts of fat loss, but an increase to 20 mg a day will provide much more in this area.

 

 

Name	CAS NO.	Usage
AICA	2627-69-2	acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown
MK286	841205-47-8	medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testorone Replacement Therapy.
MK-67	15972-10-0	for the treatment of frailty in the elderly
LGD-403	1165910-22-4	pharmacological profile similar to that of enoboarm, Ostarin,MK-286
GW5015	317318-70-0	For obesity, diabetes, dyslipidemia and cardiovascular disease
An darine(S 4)	401900-40-0	partial agonist, intended mainly for treatment of benign prostatic hypertrophy
SR900	1379686-30-2	under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice
RAD 140	1182367-47-0	New generation for gaining mass and cutting edges
YK 11	431579-34-9	YK11: a SAM and myostatin inhibitor in one
AC262356	870888-46-3	New SAMS
SR901	1379686-29-9	New SAMS
S23	1010396-29-8	New SAMS
GW072	317318-84-6	New SAMS

 
I 'm Ben

Parcels will be no problem passing customs such as Mexico ,Spain, UK, Netherlands, USA, Ireland, France, Germany, Brazil, Italy, and many European countries
WE HAVE SPECIAL SHIPPING WAY DDP delivery to your door ,safe and fast 

Our products meet the USP BP standard and we have a certificate of conformity.

Free samples will be provided

 

Related Products

Product Name	Purity
Testoste Enanthat	99%+
Testoste Cypionat	99%
Testoste Acetat	99%
Testoste Propionat	99%
Testoste Decanoat	99%
Testoste Phenylpropionat	98%+
Testoste Blend / Sustan250	99%
Testoste Undecanoat	99%
Testoste Isocaproat	99%
Fluoxymestero / Halotest	99%
Bolde undecanoat / Equipose	98%
Nandr Decanoat / Deca	99%+
Nandr Phenylpropiona/Deca Duraboli	99%+
Trenbo Acetat	99%+
Trenbo Enanthat	99%+
Trenbo Hexahydrobenzyl carbonate / Parabol	99%
Drostanol Propionat / Master Propionat	99%
Drostanol Enanthat / Master Enanthat	99%
Methenolo Acetat / Primobo Acetat	99%
Methenolo Enanthat / Primobol Enanthat	99%
Oxandro / Anav	99%
Metandien / Diana	99%
Oxymetho / Anadr	99%
Stanoz / winstr	99%
Mestero / Provir	99%
4-chlorinedehydro-methyl testoste/Turinab	99%
Methyl drostanol / Superdl /Methaste	99%
Nolva--dex	98%
Clomid	98%
Arimidex	99%
Le--tro	99%
Exe--mestane	99%
MK--677	99%+
MK--2866/Ostarin	99%
Gw--501516/Cardarine	99%
Andarin/S-4	99%
Yk11	99%
SR--9009	98%+
SR9011	99%
Ligndrol/LGD--4033	99%
RAD--140	99%
S-23	99%
Aikar	99%+
Trenavar	99%+
Halodrol	99%+
Epistane	99%+
Lorcasein	99%+
Cetilistat	99%
Orlistat	99%
tadanafil	99.5%
dapoxetine	99%
Yohimbine	98%+
Avanafil	99%
Vardenfil	99%
Benzocaine	99.5%
Lidocaine	99.5%
Procaine Hcl	99.5%
Tetracaine	99.8%
dibucaine	99.5%
Sunfiram	98%+
Noopept	98%+
Dextromethorphan Hydrobromide	98%+
Oxytocin	99%+
Bimatoprost	99%

 

 

 

 

 

Wuhan MSK Technology Co., Ltd. is one of the most dynamic research and advanced technology Manufacturer of pharmaceutical intermediates, We have set up R& D center, quality inspection center and manufacturing site in Wuhan. Our company has professional staff who deal with chemical R& D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q. A. And Q. C. System, supply chemical products with good quality and customtailored products according to our clients' requirement. We have professional sales team, focus on quality and service, and we have achieved excellent performance over 10 years. Our company is committed to the development of international market, our products are mainly exported to many countries and regions, such as Europe, America, Southeast Asia, the Middle East and Africa etc. With our constant efforts and good service, We sincerely hope to establish longterm cooperation and common development with our customers.

As a renowned manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

Our spirit of honesty, diligence. We will satisfy market demands by top products and better service, and will welcome market challenge forever. Welcome to contact if you need any help now.

1. All inquiry should be replied within 12 hours. 

2. Faster delivery would be arranged within 24hours after payment from our clients.

3. Sample is available for your evaluation & Formulation development. 

4. Quality is life of our buisness and long-termed business makes us place much emphasis on our products quality. And we must check the quality of every batch of products beforte sending out to clients . 

5.After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.

6. We need to be familiar with your Country Customs, which can decrease your trouble, let's take some examples:

Δ Poland: When you send a parcel with total weight over 2kg they are going with different service and are checked more thorough .

ΔΔ Switzerland:  If package were worth more than 20 euros and then our friends have to pay customs , moreover it means the Customs Staff opens the package, so we need to avoid more than 20 euros declared value  .

ΔΔΔ Norway: It is illegal to import any product to Norway that contains meat or milk, and we need to set the value on the order to under 35 dollars. Otherwise our friends in Norway have to pay 20% tax.

ΔΔΔΔ Colombia: We need the packages to weigh under 2kg because if it weighs more than 2kg my friend has to go to the post office to pick it up

ΔΔΔΔΔ Australia: There are two Main Customs in Australia: Customs of MELBOURNE VIC and Customs of SYDNEY NSW. As we know the latter one is very easy to pass. Different Courier Choice can make parcels go through different Customs.  We will help you choose the shipping Courier which can make sure your parcel go through easy Customs of SYDNEY NSW, and make sure success rate 100%.

ΔΔΔΔΔΔ Spain: Taxes when is here,if the order exceed 20€ the customs apply taxes in spain, so decleard valuse should be controlled under 20€  .


7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS and so on, different country needs to choose their suitable shipping company for the 100% successful delivery .

Q1: Will you supply samples for testing
A: Samples are available for most products.
 
      Q2: What's your MOQ
A: For the high value product, our MOQ starts from 10g or 100g ; For the low value product starts from 1kg.
 
            Q3: Which kind of payment terms do you accept
A:  T/T, Western Union , Money Gram and Paypal
 
                   Q4: How about your delivery time
A: →You can receive parcel photo from us within 6 hours after receiving your payment;
    →You can receive your tracking number within 24 hours after receiving your payment;
    →You can receive your parcel in 8 to 16 days .

                             Q5: How do you treat quality complaint 
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
 
                                     Q6: I buy a lot of products from China, but I every time I spend much money, time and energy in finding and buying the goods, sometimes poor goods, could you help me handle this if I can be your customer?
    we can help clients to buy solvents such as EO, BB, BA, GSO, Guaiacol when you are going to buy them ;
    we can help  clients to buy 5ml or 10ml vials  including rubber stopper, flip off cap in China at factory cost;
    we can help  clients to buy 13mm or 20mm stainless Vial crimper /Capping tool in China at factory cost;
    we can help clients to buy mechanical filter including pump, vacuum filter holder and membrane of 50mm,0.22um;
    we can help clients to buy single-punch tablet press Machine  in China at factory cost;