Top Quality Terbinafine Hydrochloride From Local Factory / CAS: 78628-80-5
China Top Quality Terbinafine Hydrochloride From Local Factory / CAS: 78628-80-5, Find details about China Terbinafine Hydrochloride, Terbinafine from Top Quality Terbinafine Hydrochloride From Local Factory / CAS: 78628-80-5
Basic Info.
Stock
Available
Usage
Amino Products
CAS
78628-80-5
Transport Package
Drum/Bag
Specification
10g/50g/100g/500g/1KG
Origin
China
Stock
Available
Usage
Amino Products
CAS
78628-80-5
Transport Package
Drum/Bag
Specification
10g/50g/100g/500g/1KG
Origin
China
Product Desciption
| Product Name | Terbinafine Hydrochloride |
| CAS No. | 78628-80-5 |
| Molecular Formula | C21H26ClN |
| Appearance | White powder |
Function
Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Research has shown that Terbinafine also reduces the ability of fungal pathogens to generate reactive oxygen species, therefore it is noted as a free radical scavenger in vitro and could potentially contain anti-inflammatory activity in vivo.
Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA
synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense
oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes.
Terbinafine is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C.
albicans). At 90-120 µM, terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human
Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA
synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense
oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes.
Terbinafine is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C.
albicans). At 90-120 µM, terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human
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