Antiasthmatic Raw Montelukast Sodium Powder 99% Purity Montelukast Sodium
China Antiasthmatic Raw Montelukast Sodium Powder 99% Purity Montelukast Sodium, Find details about China Montelukast Sodium, Montelukast Sodium Salt from Antiasthmatic Raw Montelukast Sodium Powder 99% Purity Montelukast Sodium
Antiasthmatic Raw Montelukast Sodium Powder 99% Purity Montelukast Sodium| Product name:Montelukast sodium |
| Other Name: Montelukast Sodium Salt |
| Appearance:White Powder |
| CAS:151767-02-1 |
| M.F:C35H35ClNNaO3S |
| M.W.:608.17 |
| Specification:99% |
Montelukast was launched as Singulair in Mexico and Finland for the management of mild to moderate asthma inadequately controlled by inhaled corticosteroids and short-acting beta2-agonists. Montelukast can be obtained by an seven-step synthesis from 3-[2(E)-(7-chloroquinolin-2-yl)vinyl] benzaldehyde. Montelukast is a potent, selective and orally active antagonist of the CysLT1 (formerly called LTD4) receptor, thus blocking the effects of the cysteinyl leukotrienes LTC4, LTD4 and LTE4 on microvascular permeability and the activation of eosinophils.
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| ITEM | SPECIFICATION | RESULT | METHOD |
| Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
| Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
| Specific Optical | -2.4°~ -2.8° | -2.72° | |
| Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
| Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
| Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
| Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
| Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
| pH | 4.5~7.0 | 5.10 | |
| Related substance | Spot not bigger than standard solution spot | No spot | TLC |
| Water Content | ≤2% | 0.26% | KF |
| Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
| Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
Montelukast is suitable for relieving symptoms caused by allergic rhinitis
Montelukast is used for a number of conditions including asthma, exercise induced bronchospasm, allergic rhinitis, primary dysmenorrhoea and urticaria.
Montelukast is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if they alone do not bring the desired effect.
Montelukast is also used to prevent allergic reactions and asthma flare-ups during the administration of intravenous immunoglobulin.
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