China Raw Material Domperidon/Domperidone CAS 57808-66-9, Find details about China Purity Domperidone, Material Domperidone from Raw Material Domperidon/Domperidone CAS 57808-66-9
Product Name | Domperidone |
Appearance | white powder |
CAS No | 57808-66-9 |
Delivery time | 2-3 days |
Loss on Drying | ≤1.0% |
packing | 1kg/bag |
Storage | Dry and cool place and keep away from strong light |
Payment | BTC,TT,WU,MG |
Customs | Free of customs |
Sample | avaiable |
Shelf life | 2 years |
Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%. Cel iprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater [2]. Domperidone, a dopamine antagonist that does not easily cross the blood-brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal.
Domperidone is a benzimidazole compound that has strong stomach-stimulating and antiemetic effects, can strengthen the lower esophageal sphincter tension, prevent gastric-esophageal reflux, enhance gastric motility, promote gastric emptying, and coordinate the stomach with the twelve-finger Intestinal exercise, inhibition of nausea, vomiting, and effective prevention of bile reflux, does not affect the secretion of gastric juice.
Product name | Domperidone | |
Cas number | 57808-66-9 | |
EINECS No. | 260-968-7 | |
Items | Requirements | Results |
Appearance | White to off white powder | White powder |
Solubility | Practically insoluble in water, soluble in dimethylformamide, slightly soluble in et hanol(96%) and in m ethanol | Confirms |
Identification | A. M.P. 244~248ºC | 244.5~245.5ºC |
B. IR should comply | Confirms | |
C. TLC should comply | Confirms | |
D. It gives the reaction of non-nitrogen substituted barbiturates. | Confirms | |
Clarity of solution | The solution is clear and not more intensely colored than reference solution Y6 | Confirms |
Related substance | Total impurities≤0.5% | ≤0.29% |
Individual impurity≤0.25% | ≤0.18% | |
Loss on drying | ≤0.5% | 0.07% |
Sulphated ash | ≤0.1% | ≤0.05% |
Heavy metal | ≤20ppm | <20ppm |
Assay | 99.0%~101.0% | 99.49% |
1.Domperidone is used for the treatment of gastroparesis (especially diabetic gastro-light gastroparesis), which can eliminate the symptoms of gastric retention and shorten the gastric emptying time; patients with moderate to moderate functional dyspepsia (FD) It can completely eliminate or significantly reduce symptoms such as abdominal distention, epigastric pain, belching, early satiety, nausea, and vomiting after meals.
2.Domperidone has a significant effect on reflux gastritis, but it is not very satisfactory for the efficacy of reflux esophagitis.
3.Domperidone can be used as an adjunctive treatment for peptic ulcers (mainly gastric ulcers) to eliminate antral retention.
Nausea and vomiting .There is some evidence that domperidone powder has antiemetic activity.
Domperidone powder may be useful in diabetic and idiopathic gastroparesis.
Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease,
Domperidone may be used in functional dyspepsia in both adults and children.
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Suitable for sample order or quantities<50kg Fast: 3-10 days High shipping cost Door to door service | Suitable for quantities>50kg Fast: 3-7 days Lower than express cost Airport to airport service Professional broker needed | Suitable for quantities> 300kg Slow: 7-45 days Lowest cost Port to port service Professional broker needed |