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Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4

China Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4, Find details about China Ulipristal Acetate, 126784-99-4 from Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4

Model NO.
126784-99-4
Function
Biological and Pharmaceutical Intermediates
Appearance
White Powder
MW
475.62
Delivery Time
Within 2 Days
Trademark
YINGONG
Transport Package
as Your Requirments
Specification
C30H37NO4
Origin
China
HS Code
2918120000
Model NO.
126784-99-4
Function
Biological and Pharmaceutical Intermediates
Appearance
White Powder
MW
475.62
Delivery Time
Within 2 Days
Trademark
YINGONG
Transport Package
as Your Requirments
Specification
C30H37NO4
Origin
China
HS Code
2918120000
Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4

Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4

Ulipristal acetate

Nameulipristal acetate
SynonymMore Synonyms

 Ulipristal acetate Biological Activity

DescriptionUlipristal (acetate) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
Related CatalogSignaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Endocrinology
In VitroUlipristal acetate blocks activin A modulation of fibronectin and vascular endothelial growth factor A (VEGF-A) mRNA expression in cultured myometrial and leiomyoma cells[2]. Ulipristal acetate decreases the DNA fragmentation at the 100-ng/mL dose and continuing up to the 10,000-ng/mL dose compared to those spermatozoa in the control group[3].
In VivoUlipristal and CDB-4124 have significant antiprogestational activity in vivo[1]. Ulipristal acetate decreases incidences of fibroadenomas and adenocarcinomas in the mammary gland in all treated groups. Ulipristal acetate exposure [AUC(0-24h)] at the highest dose in rats is 67 times human therapeutic exposure at 10 mg/day. In mice, no tumor of any type increases at Ulipristal acetate exposures up to 313 times of therapeutic exposure. Ulipristal acetate-related findings in mice are limited to organ weight changes in the liver, pituitary, thyroid/parathyroid glands, and epididymis as well as minimal panlobular hepatocellular hypertrophy in male and female mice receiving 130 mg/kg/day[4]. Ulipristal acetate (1 mg/kg and 5 mg/kg) increases the frequency with which pathologists assessed the endometrium as being thickened compared to controls in a dose-dependent manner. There is a slight decrease in secretory differentiation with increasing dose of Ulipristal acetate, with small decreases in frequency of sub- and supra-nuclear vacuolation[5].
SolventIn Vitro:

DMSO : 33.33 mg/mL (70.08 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

In Vivo: 1.Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution 2.Add each solvent one by one:  10% DMSO    90% corn oil Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution
Solubility
1 mM2.1025 mL10.5126 mL21.0252 mL
5 mM0.4205 mL2.1025 mL4.2050 mL
10 mM0.2103 mL1.0513 mL2.1025 mL
Animal AdminThe study consisted of four groups, each comprising four female cynomolgus monkeys. The groups eitherreceive ASV (control), or Ulipristal acetate at dose levels of 1, 5, or 25 mg/kg for 39 weeks. Two additional animals are allocated to the control and high dose groups for an 8-week post-dose recovery period. At randomization, there is no statistically significant difference between treatment groups in mean body weight. The vehicle or Ulipristal acetate is administered to all groups by oral gavage for 273 consecutive days at a dose volume of 2 mL/kg. Following the dosing or recovery period, animals are euthanized by intravenous administration of sodium pentobarbital followed by exsanguination of the femoral vessels.
Storage
Powder-20°C3 years
 4°C2 years
In solvent-80°C6 months
 -20°C1 month


Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4
Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4

Our Advantage:
1 high quality,competitive price,good service.
2. It's customers' right to choose the package ;
3.It's customers' right to choose the packing way for his produccts from many recent effective packing ways
4.Specials are possible when client's order is big enough, including the discount policy;
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time

Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4
Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4
Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4
Manufactory Raw Intermediates Ulipristal Acetate CAS 126784-99-4
Biotechnology R & D, Technology transfer, Technical Consulting, Chemical productsraw materials , for example pharmaceutical intermediates synthesis of organic compounds.
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▪ Most competitive price 
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F.A.Q
1.How is the quality?
The qualities of most products are above 99% purity, same are 99.7%  purity.
2.How is the package?
Aluminum foil bag or as customer's required.
3.How is the storage?
Keep in dry and cool place. 
4.Do I need to pay extra for shipping cost ?
No, our price includes the shipping cost already; you need not pay  for any tax and others.


 

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