China High Quality Ketoconazole CAS 65277-42-1//Voriconazole CAS 137234-62-9//Terbinafine HCl CAS 78628-80-5//Simvastatin CAS 79902-63-9//CAS 86386-73-4 Fluconazole, Find details about China Ketoconazole, CAS 65277-42-1 from High Quality Ketoconazole CAS 65277-42-1//Voriconazole CAS 137234-62-9//Terbinafine HCl CAS 78628-80-5//Simvastatin CAS 79902-63-9//CAS 86386-73-4 Fluconazole
Introduction
Name | Fluconazole |
CAS NO. | 86386 -73-4 |
Molecular formula | C13H12F2N6O |
Assay | 99% |
Characteristic | White crystalline powder |
Molecular weight | 306.27 |
Function
Fluconazole is indicated for the treatment and prophylaxis of fungal infections where other antifungals have failed or are not tolerated (e.g., due to adverse effects), including:
Candidiasis caused by susceptible strains of Candida Tinea corporis, tinea cruris or tinea pedis,Onychomycosis, Cryptococcal meningitis
Fluconazole can be used first-line for the following indications:
Coccidioidomycosis,Cryptococcosis,Histoplasmosis,Prophylaxis of candidiasis in immunocompromised people,
Auto-brewery syndrome
Fluconazole is active against:
Blastomyces dermatitidis,Candida spp. (except C. krusei and C. glabrata),Coccidioides immitis,Cryptococcus neoformans
Epidermophyton spp,Histoplasma capsulatum,Microsporum spp,Trichophyton spp.
Items | Standards | Results |
Description | White or almost white crystalline powder | Complies |
Identification | By IR | Complies |
By UV | Complies | |
Solubility | Freely soluble on methanol, soluble in alcohol and in acetone, sparingly soluble in isopropanol and in chloroform, slightly soluble in water and toluene | Complies |
Clarity and color of solution | The solution to be clear and colorless | Complies |
Loss on drying | ≤ 0.5% | 0.3% |
Residue on ignition | ≤ 0.1% | 0.05% |
Iron | ≤ 20ppm | Complies |
Related compounds | Impurity at RRT 0.6: ≤1.00% | 0.16% |
Related compound A: ≤0.20% | 0.13% | |
Related compound B: ≤0.10% | 0.01% | |
Related compound C: ≤0.2% | ND | |
Any other individual impurity: ≤0.10% | 0.06% | |
Total unknown impurities: ≤0.30% | 0.12% | |
Total impurities ≤1.5% | 0.41% | |
Assay | 98.0%~102.0% | 99.80% |
Reference Standard | USP Standard | |
Conclusion | The product complied to USP standard. | |
Storage Condition | Preserve in tight,light-resistant containers, stored at room temperature and protect from light |