CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China

CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China, Find details about China 58186-27-9, 58186-27-9 Powder from CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China

Model NO.
qige
Storage
Keep in a Cool and Dry Place
Molecular Formula
C19h30o5
MW
338.44
Trademark
qige
Transport Package
Drum
Specification
99%
Origin
China
Model NO.
qige
Storage
Keep in a Cool and Dry Place
Molecular Formula
C19h30o5
MW
338.44
Trademark
qige
Transport Package
Drum
Specification
99%
Origin
China
 Gurantee 100% safe shipping, free of EU customs clearance. We will ship by special line that shipping company do custom clearance and deliver to door. 100% safe deliver
 

CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone For Cerebral Infarction

Name: Idebenone
Synonyms:4-dione,5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-5-cyclohexadiene-1;6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone;2-(10-Hydroxy-Decyl)-5,6-Dimethoxy-3-Methyl-[1,4]Benzoquinone;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione;idebonone
CAS:58186-27-9
MF:C19H30O5
MW:338.44
Chemical Properties:Yellow-Orange Crystalline Solid
Usage:Cognition enhancer, nootropic.Ubiquinone derivative with protective effects against cerebral ischemia.
Biological Activity:Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo . Inhibits apoptosis of astrocytes via increased NGF production.
Mechanisms: Idebenone (particularly its reduced form) is highly antioxidative, with IC50 values against oxidative damage in the range of 0.5-10µM.

Description

Idebenone is an organic compound belonging to the quinone family, being similar to coenzyme Q-10. However, these have been not very much progress associated with this indication. It is now also used for the treatment of Friedreich's ataxia with a positive effect on cardiac hypertrophy and neurological function. 

However, this indication is only approved in Canada, not in Europe and US. It is now under investigation on its efficacy for the treatment of Duchenne muscular dystrophy, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) as well as primary progressive multiple sclerosis. The efficacy of this drug still demands more evidences.

Application

1) Memory and Learning

Impairments (via age or injury) in passive avoidance retention, working memory, and delayed alternation can be reduced or reversed by pretraining administration of 3-30mg/kg idebenone For acute usage, 30mg/kg appears to be optimal when injected (intraperitoneal) whereas 3mg/kg injections are sufficient for chronic studies.

2) Alzheimer's

Idebenone has been found to be neuroprotective against β-amyloid peptides which is thought to be related to the antioxidative properties of idebenone (as antioxidants, per se, are neuroprotective). These protective effects have been confirmed in vivo as assessed by a reduction in memory loss.

3) Glutaminergic Neurotransmission

In vitro, Idebenone can reduce glutamate-induced toxicity in the range of 0.1-3µM secondary to its antioxidative properties, and at a potency exceeding Vitamin E (requiring 10-100µM) and Vinpocetine (10-100µM). It also appears effective against excitotoxicity associated with ATP depletion (independent of NMDA receptors, but still from glutamate) secondary to its antioxidative effects.

Unlike many other compounds, Idebenone appears to be protective against excitotoxicity mediated via the AMPA and kainate receptors but not NMDA although some general neuroprotection from the antioxidative effects may persist on NMDA (as noted elsewhere).

Ischemia (damaging via glutamate) appears to be protected against with idebenone (100mg/kg intraperitoneal injections) and secondary to that a preservation of memory (losses seen with ischemic control).


CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China


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CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China
CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China
CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China


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Drug Eutylone /EU CAS 802855-66-9


 

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CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China

CAS 58186-27-9 Pharmaceutical Raw Materials Idebenone for Cerebral Infarction Made in China