Polyclonal Primary Antibodies Anti - Heme -Regulated Inhibitor Rabbit Pab
China Polyclonal Primary Antibodies Anti -Heme-Regulated Inhibitor Rabbit Pab, Find details about China Primary Antibody, Antibodies from Polyclonal Primary Antibodies Anti -Heme-Regulated Inhibitor Rabbit Pab
Basic Info.
Model NO.
GB111094
Model No
GB111094
Size
100UL
Sterilization
Pre-Sterile with Radiation
Concentration
1mg/1ml
Instrument Classification
Class I
Type
Pathological Analysis Equipments
Host Animal
Rabbit
Isotype
Igg
Application
Ihc, If, Wb
Storage
-20ºC
Package
Bottle with Ice, Individual Foil Pouch
Samples
Available
Species
Human, Mouse, Rat
Trademark
Servicebio
Transport Package
Standard Export Carton
Specification
100ul/pc
Origin
Wuhan, China
HS Code
3502900000
Model NO.
GB111094
Model No
GB111094
Size
100UL
Sterilization
Pre-Sterile with Radiation
Concentration
1mg/1ml
Instrument Classification
Class I
Type
Pathological Analysis Equipments
Host Animal
Rabbit
Isotype
Igg
Application
Ihc, If, Wb
Storage
-20ºC
Package
Bottle with Ice, Individual Foil Pouch
Samples
Available
Species
Human, Mouse, Rat
Trademark
Servicebio
Transport Package
Standard Export Carton
Specification
100ul/pc
Origin
Wuhan, China
HS Code
3502900000
Product Desciption
Polyclonal Primary Antibodies Anti -Heme-regulated inhibitor Rabbit pAb
Applications
Background
The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.
Images
Storage
Product Information
| Description | Heme-regulated inhibitor rabbit polyclonal |
| Protein full name | Eukaryotic translation initiation factor 2-alpha kinase 1 |
| Synonyms | Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Eif2ak1, Heme-controlled repressor, HCR, Heme-regulated inhibitor, Hri |
| Immunogen | Recombinant protein corresponding to Mouse Heme-regulated inhibitor |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm |
| Predicted MW. | 70 kDa |
| Observed MW. | 70 kDa |
| Uniprot ID | Q9BQI3, Q9Z2R9, Q63185 |
Applications
| Applications | WB | IHC | IF |
| Species | Human, Mouse, Rat | Mouse, Rat | Mouse, Rat |
| Dilution | 1: 500-1: 1000 | 1: 1000-1: 2000 | 1: 500-1: 1000 |
| Positive tissue | HEK293 | bone, lung, inflammation lung | bone, lung, inflammation lung |
Background
The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.
Images
 | Western blot analysis of Eif2ak1 (GB111094) at dilution of 1: 1000 Lane 1: HEK293 cell lysate |
 | Immunohistochemistry analysis of paraffin-embedded mouse bone using Eif2ak1 (GB111094) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded rat lung using Eif2ak1 (GB111094) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded mouse inflammation lung using Eif2ak1 (GB111094) at dilution of 1: 1000 |
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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