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Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.

In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013

Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.

The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease.

Pirfenidone may also be used for purposes not listed in this medication guide.

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In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.













Xi'an Tian Guangyuan Biotech Co., Ltd.

Sophie Lee/Sales Manager

Tel: 86-29-86333380

Web:tgybio.en.made-in-china.com






XIAN Tian Guangyuan Biotech Co.,Ltd.Was founded in May 2003, is a professional animal and plant Extracts
modernand advanced enterprise object, chemical intermediates and active ingredients of Natural active
throughout the country,plant extracts industry, research and development, production,Marketing and other
areas have a strong strength.The company is headquartered in the outskirts of Xi'an, under research and
development center as well as analysisand testing center, comprehensive strength in the national forefront
of the industry.Companies rely on the wisdom andinnovation of advanced technology, scientific management
and all the staff and a good team spirit, will enable the companyto develop a domestic industry with sik-class
product quality and international competitiveness of enterprises.