In vitro, pirfenidone can inhibit the proliferation of uterine leiomyoma cells and leiomyoma cells. Pirfenidone inhibits the formation of collagen in TGF-β-1-induced fibroblasts. Inhibition of PDGF, FGF and TGF-β-1 induced fibroblast proliferation. In the hamster model, pirfenidone, orally, prevents and treat bleomycin-induced pulmonary fibrosis. Pirfenidone can prevent chemically induced rat sclerosing peritonitis and can also be treated with keloid transplantation for nude mice.

Pirrenidone 0.01 1 mg / ml can inhibit the matrix and dose-dependent manner of serum stimulation of uterine fibroids and leiomyoma cell DNA synthesis, the compound without cytotoxicity, the collagen mRNA levels have no effect. Pirfenidone in the hamster pulmonary fibrosis model can reduce the level of collagen I mRNA levels before the disease, reduce lung proline levels and malondialdehyde and lung preservation of amino acid hydroxylase activity.

Application

Pirfenidone is an antiinflammatory drug used to treat idiopathic pulmonary fibrosis. Anti-fibrosis agents, effective lung and pulmonary fibrosis models. Inhibit collagen production and fibroblast proliferation. Regulate the level of cytokines after oral administration of the body. Free radical scavengers and lipid peroxidation inhibitors. Pirfenidone inhibits collagen production and fibroblast proliferation. Antibacterial and antiinflammatory properties have been shown in various pulmonary fibrosis animal models and in clinical trials.

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Xi'an Tian guangyuan Biotech Co.,Ltd.

Tel: 86-29-86333380

Fax: 86-29-86333380

Web:tgybio.en.made-in-china.com

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Company information

XIAN Tian Guangyuan Biotech Co.,Ltd.was founded in May 2003, is a professional animal and plant extracts modern and advanced enterprise object, chemical intermediates and active ingredients of natural active throughout the country, plant extracts industry, research and development, production, marketing and other areas have a strong strength. The company is headquartered in the outskirts of Xi'an, under research and development center as well as analysis and testing center, comprehensive strength in the national forefront of the industry. Companies rely on the wisdom and innovation of advanced technology, scientific management and all the staff and a good team spirit, will enable the company to develop a domestic industry with sik-class product quality and international competitiveness of enterprises.

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