China S-Arms Raw Material Factory Direct Supply 99% Purity CAS 317318-70-0 Gw-5015-16

China S-Arms Raw Material Factory Direct Supply 99% Purity CAS 317318-70-0 Gw-5015-16, Find details about China 99% Purity, Chemical Materials from China S-Arms Raw Material Factory Direct Supply 99% Purity CAS 317318-70-0 Gw-5015-16

Basic Info.

Model NO.

317318-70-0

Appearance

White Powder

Molecular Formula

C21h18f3no3s2

Grade

Pharmaceutical Grade

Product Name

Gw 50-1516

CAS No

317318-70-0

Molecular Weight

453.5

Trademark

Wingroup

Transport Package

Drum / Aluminum Foil Bag

Origin

Wuhan, China

Model NO.

317318-70-0

Appearance

White Powder

Molecular Formula

C21h18f3no3s2

Grade

Pharmaceutical Grade

Product Name

Gw 50-1516

CAS No

317318-70-0

Molecular Weight

453.5

Trademark

Wingroup

Transport Package

Drum / Aluminum Foil Bag

Origin

Wuhan, China

Product Desciption

Product Name	GW-50,1,516
Synonyms	2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]aceticacid;GW-5,01,516,>=98%;ENDUROBOL(GW-5,015,16)/CARDARINE/;Cardarine(GW-5,01,516,GSK-516);GW-501615;CB646Chemicalbook5728;2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetica;{2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-aceticacid
CAS NO	317318-70-0
Molecular Formula	C21H18F3NO3S2
Molecular Weight	453.5
Melting point	134-136°C
Boiling Point	584.5±60.0 °C at 760 mmHg
Flash Point	307.3±32.9 °C
Density	1.4±0.1 g/cm3
Purity	≥97%
Grade	Pharmaceutical Grade
Solubility	DMSO: soluble20mg/mL, clear
Appearance	white to beige powder
Storage	Store at dry and cool place
Packing and Shipping	Packing: Drum / Aluminum Foil Bag / According to customer's requiement Shipping: 3-5 working days after receive payment, by Fedex,UPS,EMS,DHL,Sea and air transport
Usage	It is the best in terms of endurance, energy, endurance and any type of performance improvement

Description:

GW-5,01,516 (also known as GW-5,01,516, GW-1516, GSK-516, Cardarine, is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. It entered into clinical development as a drug candidate for metabolic and cardiovascular diseases.

Exercise can increase peroxisome proliferator-activated receptor-δ (PPARδ) expression in skeletal muscle. PPARδ regulates muscle metabolism and reprograms muscle fibre types to enhance running endurance. This study utilized metabolomic profiling to examine the effects of GW-501,516, a PPARδ agonist, on running endurance in mice.

Reference:

1. Koh B (2013-03-22). "Anti-doping agency warns cheats on the health risks of Endurobol". The Conversation.

2. Sahebkar A, Chew GT, Watts GF (March 2014). "New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease". Expert Opinion on Pharmacotherapy. 15 (4): 493-503. doi:10.1517/14656566.2014.876992. PMID 24428677. S2CID 21158696. Despite these promising early results, the further investigation and development of GW-501,516 was discontinued after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes

3. "GW-5,01,516 GlaxoSmithKline, Ligand milestone payment". R & D Focus Drug News. 28 June 2004.

4. Wolf G (November 2003). "The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis". Nutr. Rev. 61 (11): 387-90. doi:10.1301/nr.2003.nov.387-390. PMID 14677574. S2CID 12362203.

5. Oliver WR, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM (April 2001). "A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport". Proc. Natl. Acad. Sci. U.S.A. 98 (9): 5306-11. Bibcode:2001PNAS...98.5306O. doi:10.1073/pnas.091021198. PMC 33205. PMID 11309497.