Synthetic Anti-Infective Drugs CAS 738-70-5 Trimethoprim for Animal

China Synthetic Anti-Infective Drugs CAS 738-70-5 Trimethoprim for Animal, Find details about China Trimethoprim, Tmp from Synthetic Anti-Infective Drugs CAS 738-70-5 Trimethoprim for Animal

Basic Info.

Model NO.

HNB-178

Trademark

HNB-Biotech

Origin

Shaanxi, China

Model NO.

HNB-178

Trademark

HNB-Biotech

Origin

Shaanxi, China

Product Desciption

Synthetic anti-infective drugs CAS 738-70-5 Trimethoprim for Animal

Product name	Trimethoprim
Cas No.	738-70-5
Molecular Formula	C₁₄H₁₈N₄O₃
Appearance	White crystalline powder

Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections.Target: DHFRTrimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthetase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug combination also reduces the development of resistance that is seen when either drug is used alone.