Gastric ulcer, duodenal ulcer, stress ulceration, reflux esophagitis, or Zollinger-Ellison syndrome (gastrinomas).

PHARMACOKINETICS
Omeprazole was absorbed from small intestines after oral administration. The onset of the antisecretory effect of omeprazole occurred within one hour. Peak blood concentration of omeprazole was reached within 0.5 to 3.5 hours and the duration of inhibition lasted up to 24 hours. Omeprazole can be distributed in liver, kidney, duodenum and thyroid gland, and can pass through placenta easily. Usually, bioavailability is about 35% at a single dose and can be increased to 60 % at multiple doses. Protein binding is 95 % to 96 %. The plasma half-life is 0.5 to 1 hour in healthy subjects and is 3 hours in patients with chronic liver diseases. Omeprazole is metabolized by the cytochrome P450 oxidizing enzyme system of liver microsome in vivo, 80 % of metabolite was eliminated in urine, the remainder was excreted via bile and then eliminated in feces.

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Company Profile

1)Lunan Pharmeceutical Group is a large and comprehensive pharmacutical enterprise, a major national innovative enterpre and States Key High New Technology Enterprise that produces, researches and sells traditional Chinese medicine, chemical medicine and biological medicine.

2)The group is comprised of seven subsidiary companies including Lunan Hope Pharmaceutical Co., Ltd., Lunan Better Pharmaceutical Co., Ltd., Shandong New Time Pharmaceutical Co., Ltd., Lunan New Time Medical Co., Ltd. etc...It is one of the top 500enterprises of China, and it has been the top 100 taxpayer for 8 years in Shandong province. 

Our Advantages

Our group is equipped with high R&D Platforms, such as National Chiral Pharmaceutical Engineering Technology Research Center, National Mammalian Cells Efficiently Express Engineering Laboratory, State Key Laboratory of Generic Marufacture Technology of TcM, National Enterprise Techecogy center, Postdoctoral Programme andTaishan Scholars Position.

The group built up a long technology partnership with more than 100 institutes and universities at home and abroad meanwhile it enhances its own independent innovation system. Lunan Enterprise Technology center's technology innovative ability ranks the forefront in Pharmaceutical industry and got the title"Top Ten Best Industrial Enterprises of Domestic Pharmaceutical R & D Product Line".